1General term for a variation in the normal coloration of Red Blood Cells
Anisochromia
2The normal diameter of the central area of pallor in an RBC
approximately 1/3 the diameter
3Description of hypochromic cells
central pallor > 1/3 of diameter; usually microcytic
4Anemia types where hypochromic cells may be found
Sideroblastic anemias and iron deficiency anemia
5Grading for hypochromia when the area of central pallor is 1/2 of the diameter
1+
6Grading for hypochromia when the area of central pallor is 2/3 of the diameter
2+
7Grading for hypochromia when the area of central pallor is 3/4 of the diameter
3+
8Grading for hypochromia when there is only a thin rim of hemoglobin
4+
9Other names for an Anulocyte
Ghost cell or Pessary cell
10Morphological description of an Anulocyte
RBC with a thin rim of hemoglobin and a large, clear center
11Description of hyperchromic cells
RBCs that lack central pallor even though they lie in a desirable area
12The actual cause of "hyperchromic" RBCs in spherocytes
shape change
13The lab value that is HIGH in true hyperchromia
MCHC
14The basically only disease in which the MCHC is high (above reference range)
Hereditary Spherocytosis (HS)
15Reference range for MCHC
31 to 37 g/dL
16The MCHC range typically found in Hereditary Spherocytosis
35 to 38 g/dL
17Identify the three key clinical manifestations of symptomatic Hereditary Spherocytosis
Splenomegaly, anemia, and jaundice
18The result of a Direct Antiglobulin Test (DAT) in Hereditary Spherocytosis
negative
19Result of MCV, MCH, and MCHC in Hereditary Spherocytosis
MCV (normal to low), MCH (normal), MCHC (slightly increased)
20Immune disorders that have spherocytes are characterized by this result on the DAT
positive (+)
21Diagnostic test for HS that is greatly increased but can be corrected with glucose or ATP
Autohemolysis test
22The screening test for HS which shows "increased" results but is NOT diagnostic
Osmotic Fragility Test (OFT)
23Anticoagulant required for the Osmotic Fragility Test
Heparin
24Confirmatory test for HS that uses flow cytometry to measure fluorescence
EMA binding test
25Description of polychromatophilic erythrocytes
larger than normal red cells with a bluish tinge (Wright's stain)
26The cause of the bluish tinge in polychromatophilic erythrocytes
presence of residual RNA
27Condition associated with large numbers of polychromatic cells
decreased RBC survival, hemorrhage, or erythroid hyperplastic marrow