Anisochromia
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1
General term for a variation in the normal coloration of Red Blood Cells
Anisochromia
2
The normal diameter of the central area of pallor in an RBC
approximately 1/3 the diameter
3
Description of hypochromic cells
central pallor > 1/3 of diameter; usually microcytic
4
Anemia types where hypochromic cells may be found
Sideroblastic anemias and iron deficiency anemia
5
Grading for hypochromia when the area of central pallor is 1/2 of the diameter
1+
6
Grading for hypochromia when the area of central pallor is 2/3 of the diameter
2+
7
Grading for hypochromia when the area of central pallor is 3/4 of the diameter
3+
8
Grading for hypochromia when there is only a thin rim of hemoglobin
4+
9
Other names for an Anulocyte
Ghost cell or Pessary cell
10
Morphological description of an Anulocyte
RBC with a thin rim of hemoglobin and a large, clear center
11
Description of hyperchromic cells
RBCs that lack central pallor even though they lie in a desirable area
12
The actual cause of "hyperchromic" RBCs in spherocytes
shape change
13
The lab value that is HIGH in true hyperchromia
MCHC
14
The basically only disease in which the MCHC is high (above reference range)
Hereditary Spherocytosis (HS)
15
Reference range for MCHC
31 to 37 g/dL
16
The MCHC range typically found in Hereditary Spherocytosis
35 to 38 g/dL
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Identify the three key clinical manifestations of symptomatic Hereditary Spherocytosis
Splenomegaly, anemia, and jaundice
18
The result of a Direct Antiglobulin Test (DAT) in Hereditary Spherocytosis
negative
19
Result of MCV, MCH, and MCHC in Hereditary Spherocytosis
MCV (normal to low), MCH (normal), MCHC (slightly increased)
20
Immune disorders that have spherocytes are characterized by this result on the DAT
positive (+)
21
Diagnostic test for HS that is greatly increased but can be corrected with glucose or ATP
Autohemolysis test
22
The screening test for HS which shows "increased" results but is NOT diagnostic
Osmotic Fragility Test (OFT)
23
Anticoagulant required for the Osmotic Fragility Test
Heparin
24
Confirmatory test for HS that uses flow cytometry to measure fluorescence
EMA binding test
25
Description of polychromatophilic erythrocytes
larger than normal red cells with a bluish tinge (Wright's stain)
26
The cause of the bluish tinge in polychromatophilic erythrocytes
presence of residual RNA
27
Condition associated with large numbers of polychromatic cells
decreased RBC survival, hemorrhage, or erythroid hyperplastic marrow
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