1humoral cell response
B cells recognize a specific antigen with BCR and produce antibodies
can take a while
2cell mediated response
MHC 1 presents antigen to CD8 T cells that are then activated and stimulate apoptosis
3antigen
molecules recognized as non self
4antibody
immunoglobulins that have 2 antigen binding sites and are made of 2 heavy and 2 light chains
5function of macrophages
undergo phagocytosis
6function of dendritic cells
capture and present antigens to T cell
express MHC 2
7function of FDCs
trap antigens to hold for B cell interaction
8function of B cells
recognize antigen in many forms and dont require MHC
produce antibodies
9MHC class 1
on all nucleated cells
signal to CD8 cells
have a heavy alpha chain and beta-2-microglobulin chain
10MHC class 2
on all pro APCs
signal to CD4 cells
two peptide chains of more equal size
11function of IgG
neutralizes toxins and opsinizes bacteria
can cross placenta
makes up 70-80% of plasma
12function of IgM
pentamer
first after immunization
helps with antigen recognition and activation
13function of IgA
in mucosa, tears, sweat, bile, breast milk
stops bacteria and viruses from entering epithelium
14function of IgE
releases histamine and leukotrienes and recruits eosinophils
fights parasitic infections
involved in hypersensitivity
15function of IgD
helps with antigen recognition and activation
16primary lymphoid tissue
bone marrow and thymus
17secondary lymphoid tissue
lymph nodes, spleen, and malt
18function of T lymphocytes in cell mediated immunity
CD8 T cells secrete cytokines that directly kill the infected cells
CD4 cells release cytokines that help stimulate B cells to make antibodies