1characterized by a failure of control of energy production
Diabetes Mellitus
2What are the long-term consequences of diabetes? (3)
Blindness, cardiovascular disease, and renal failure.
3What are the risk factors for diabetes? (3)
Malnutrition, lack of exercise, and excessive calorie intake
4Diabetes predisposition can be inherited but influenced by _______
Environment
5______ insulin demand
______ insulin action
______ insulin production
Increase insulin demand
Oppose insulin action
Suppress insulin production
6If the defect is in the pancreas, there may be inadequate number of __________________
Islets of Langerhans
7Insulin is initially synthesized as ______ and later converted into active insulin through proteolysis.
Proinsulin
8Which hormones stimulate insulin production? (4)
1. Glucagon
2. Gastric Inhibitory Peptide
3. Gastrin
4. Pancreozymin
9What are the functions of insulin? (5)
1. Glucose utilization
2. Fatty acid synthesis
3. Reduces lipolysis in adipose tissue
4. Amino acid uptake
5. Protein synthesis
10What are the three primary actions of insulin?
1. Increased transport and utilization of glucose
2. Reduced gluconeogenesis and glucose release in the liver
3. Reduced loss of amino acids
11What are the catabolic hormones for insulin? (3)
Glucagon, Adrenal Glucocorticoids, Growth Hormone
12Insulin promotes the conversion of glucose into ________, _______, ______, and _____, resulting in a lowering of blood glucose concentration.
CO2, Fatty Acids, Lactate, and Glycogen
13a consequence of reduced peripheral uptake and utilization of glucose and the
increased production of glucose by the liver.
Hyperglycemia
14In insulin deficiency, the production of glucose from glucose precursors (2)
Lactic acid and Most amino acids
15In untreated diabetic individuals, there is a lack of ____ and excess of ____
Insulin, Glucagon
16Even though food intake is in excess. only a ____ amount of glucose is converted into glycogen due to the lack of insulin. Glucose remains in the blood.
Small
17Untreated diabetics have a ___ nitrogen balance, ____ lean body mass, and weight ___.
Negative, Decreased, Loss
18are those that can be reversed quickly with the adjustment of blood glucose level
Acute Complications
19are largely the consequence of microvascular lesions.
Chronic Complications
20usually defined as blood glucose <70 mg/dl, is also known as an insulin reaction or insulin shock. It occurs when blood glucose concentrations become subnormal.
Hypoglycemia
21This type of acute complication can occur in extreme levels of hyperglycemia, but acidosis does not develop. Typical in patients more than 50 years old and non-insulin dependent diabetes
Hyperosmolar nonketotic coma
22Where excess glucose is converted into sorbitol and fructose in the blood.
Sorbitol pathway
23Where there is increased synthesis of glycoproteins in diabetics.
Glycoprotein formation
24where larger proportions of carbohydrate lead to greater amount of glucose available to their synthetic pathway, thus may cause alterations in their structure.
Mucopolysaccharide
25Anatomic and physiologic lesions include? (4)
1. Angiopathy
2. Nephropathy
3. Neuropathy
4. Retinopathy
26disease in large blood vessels, small blood vessels?
Macroangiopathy, Microangiopathy
27progresses without symptoms until renal failure is far advanced.
Nephropathy
28It may occur in either the sensory or motor nerves or both.
Neuropathy
29_________ in the diabetics is a common cause of blindness.
Retionopathy
30determined in venous or capillary blood or plasma from an individual following an overnight fast, usually eight hours. ___mg/dL is indicative of diabetes
Fasting plasma glucose or Fasting blood glucose; 126 mg/dL
31A high____ concentration will fall only as cells die and are replaced by
new cells, but will not fall with a temporary decrease in the blood
glucose level. More or equal to _% indicates diabetes
Glycosylated hemoglobin (HbA1c), 7.0
32is recommended to establish a diagnosis of diabetes or impaired glucose tolerance in asymptomatic individuals whose FPG is between 110 and 140 mg/dl of plasma. It is based on the assumption that a normal individual can remove a specified glucose load from the blood within a specified period.
Oral glucose tolerance test (OGTT)
33A __ g glucose solution in a 15-25% lemon flavored solution must be ingested within __ minutes, and hourly glucose content of plasma samples is determined.
75, 15
34is when diabetic individuals are taught how to monitor their blood glucose, keep records of their values so that adjustments can be made to respond to fluctuations in blood glucose levels.
Self-blood glucose monitoring (SBGM)
35HbA1c is also used as a monitoring tool to indicate the average blood glucose level over the previous ___ to _____-month period,
Two to Three
36What are the specific objectives for MNT? (5)
1. Relieve symptoms
2. Maintain near-normal blood glucose levels
3. Decrease severity of disease
4. Prevent or correct complications
5. Assure adequate nutrition
37What are the four facets of nutritional care?
a. Control of the dietary intake to decrease clinical manifestations while providing for nutritional needs;
b. Use of hypoglycemic drugs;
c. Exercise; and
d. Education
38stimulate the release of preformed insulin from the pancreas.
Sulfonylureas
39What are the three types of insulin?
rapid-acting, intermediate-acting, and long-acting.
40Limit protein intake for adults to ___ g/kg body weight
0.8
42saturated fat and polyunsaturated fat comprising __% or less each and monounsaturated fat the remaining __% or more
10,10
43Restrict cholesterol intake to ___ mg/day or less
3000
44Carbohydrates should be unrefined with fiber to equal up to __ g soluble fiber per day
40
45Restrict sodium intake to ____ mg per 1000 kcal
1000
46Estimating total calorie needs is based on?
Ideal Body Weight
47are compounds that give sweetness without contributing significantly to calories and do not cause dental caries.
Nonnutritive sweeteners
48They are essentially free and at least ___ times sweeter than sucrose.
30