Influenza

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1
Disease Classification
Influenza (flu)
2
Causative Agent
Influenza Virus
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Classification of the Flu
Multi-strand(8 segments) RNA genome, Virion 80-200nm, Enveloped, Hemagglutinin (HA) Spikes, Neuraminidase (NA) Spikes
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Hemagglutinin Spikes
attach and allow entry into the cell
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Neuraminidase (NA) Spikes
Escape of viruses
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Reservoir
Humans and other vertebrates
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Portal of Entry
Respiratory Tract
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Incubation Period
1-2 days
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Pathogenesis
HA spikes gain entry via ciliated epithelial cells. Viruses replicate and spread to other cells of lower respiratory tract including aleolar cells. damage to mucocillary escalator results in secondary bacterial infections
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Symptoms
fever, cough, sore throat, runny/stuffy nose, body aches, headaches, chills, fatigue, sometimes diarrhea and vomiting. Usually resolve within ONE WEEK
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Symptoms with more serious conditions
Difficulty breathing or shortness of breath, pain/pressur in chest or abdomen, sudden dizziness, confusion, severe or persitant vomiting,
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Complications
Upper respiratory tract infection, ear infections, worsening of asthma or other chronic conditions, pneumonia, inflammation of heart, brain,and kidneys, sepsis, death
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Prevention
everyday preventative measure, wash your hands
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Treatment
Rest, drink fluids, Antivrial drugs- NA inhibitors or M2 inhibitiors
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