Oxidative Phosphorylation

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1
Main Stages
Electron Transport Chain (ETC) and Chemiosmosis.
2
Electron Transport Chain
Series of proteins that transfer electrons from NADH/FADH₂ to oxygen.
3
Proton Gradient
H⁺ concentration difference across inner membrane created by ETC.
4
ATP Synthase
Enzyme that uses proton flow to synthesize ATP from ADP + Pi.
5
Final Electron Acceptor
Oxygen (O₂) forming water after accepting electrons.
6
Chemiosmotic Gradient
Potential energy stored in proton gradient used for ATP production.
7
Total ATP Yield per Glucose
~34 ATP from oxidative phosphorylation (≈36 total including glycolysis & CAC).
8
Uncouplers
Substances that dissipate proton gradient, reducing ATP output and producing heat.
9
Cyanide/CO Effect
Block ETC by binding to complex IV → halts ATP production and cell death.
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