1The molecular formula of Simvastatin is
C25H38O5
21H-pyrrolo[3,4-b]quinolin-1-one
3A bicyclic structure with a
benzene ring fused to a pyridine ring.
quinolin
4 A five-membered ring
containing nitrogen.
pyrrolo
5 This tells us how the pyrrole ring
is attached to the quinoline. The "b"
indicates that the pyrrole is fused to the "b"
face of the quinoline. The 3 and 4 indicate
the specific carbons on the quinoline where
the fusion occurs.
3,4-b
6This specifies the position of the
hydrogen atom on the pyrrole ring.
1H
7This tells us that the ketone
(C=O) is located at the 1-position of the
entire fused ring system.
-1-one
8 This indicates that some of
the rings in the core structure are saturated
(contain only single bonds between carbon
atoms), meaning that they are hydrogenated
octahydro
9 This tells us there are two
methyl groups (CH₃) attached to the core
structure, one at position 3 and the other at
position 7.
3,7-dimethyl
10simvastatin brands
zocor
simlup
lapidil
lypostat
flolipid
11primarily used for its
cholesterol-lowering effects.
simvastatin
12therapeutic uses
hyperlipidemia
prevention of cardiovascular disease
atherosclerosis
post-heart attack management
prevention of stroke
familial hypercholesterolemia
prevention of cad
13moa
prodrug activation
inhibition of HMG-CoA reductase
decreased cholesterol synthesis
upregulation of ldl receptors
increased ldl clearance from blood
cardiovascular benefits
14dosage form
tablets
oral suspension