SIMVASTATIN

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1
The molecular formula of Simvastatin is
C25H38O5
2
1H-pyrrolo[3,4-b]quinolin-1-one
3
A bicyclic structure with a
benzene ring fused to a pyridine ring.
quinolin
4
A five-membered ring
containing nitrogen.
pyrrolo
5
This tells us how the pyrrole ring
is attached to the quinoline. The "b"
indicates that the pyrrole is fused to the "b"
face of the quinoline. The 3 and 4 indicate
the specific carbons on the quinoline where
the fusion occurs.
3,4-b
6
This specifies the position of the
hydrogen atom on the pyrrole ring.
1H
7
This tells us that the ketone
(C=O) is located at the 1-position of the
entire fused ring system.
-1-one
8
This indicates that some of
the rings in the core structure are saturated
(contain only single bonds between carbon
atoms), meaning that they are hydrogenated
octahydro
9
This tells us there are two
methyl groups (CH₃) attached to the core
structure, one at position 3 and the other at
position 7.
3,7-dimethyl
10
simvastatin brands
zocor
simlup
lapidil
lypostat
flolipid
11
primarily used for its
cholesterol-lowering effects.
simvastatin
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therapeutic uses
hyperlipidemia
prevention of cardiovascular disease
atherosclerosis
post-heart attack management
prevention of stroke
familial hypercholesterolemia
prevention of cad
13
moa
prodrug activation
inhibition of HMG-CoA reductase
decreased cholesterol synthesis
upregulation of ldl receptors
increased ldl clearance from blood
cardiovascular benefits
14
dosage form
tablets
oral suspension
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