1Agenesis of the Corpus Callosum
* Begins to develop at 8 weeks of gestation.
* Is not complete until 18 - 19 weeks.
The cause is unclear.
* Thought to involve vascular disruption or inflammatory lesion before 12 weeks.
2When does Agenesis of the Corpus Callosum (ACC) begin?
Begins to develop at 8 weeks of gestation.
3When is Agenesis of the Corpus Callosum complete?
Is not complete until 18 - 19 weeks.
What is the cause of agenesis (ACC)?
4ACC - Agenesis of the Corpus Callosum
The cause is unclear.
* Thought to involve vascular disruption or inflammatory lesion before 12 weeks.
5What is corpus callosum?
A fibrous white matter tract that connects the cerebral hemispheres and aids in the cognition and neurological functions.
6What does "Dysgenesis of corpus callosum" describe?
Range of complete to partial absence of callosal fibers that cross the midline, forming a connection between the two hemispheres.
7What is Agenesis of the Corpus Callosum (ACC) also known as?
Callosal agenesis
8When does Agenesis of the Corpus Callosum (ACC) occur?
Occurs sporadically
9What other malformations are associated with Agenesis of the Corpus Callosum (ACC)?
May be associated with other CNS malformations:
- Hydrocephalus
- gyral anomalies
- Heterotopias
- DWM
- holoprosencephaly
10What manners may Agenesis of the Corpus Callosum (ACC) be transmitted?
May be transmitted in autosomal-dominant or autosomal-recessive manner.
11In Agenesis of the Corpus Callosum (ACC) what syndromes have been identified?
X-linked syndromes have been idenified.
12What chromosomal anomalies may accompany Agenesis of the Corpus Callosum (ACC)?
- Trisomies 21
- Trisomies 13
- Trisomies 18
- Triploidy.
13What other syndromes have been associated with Agenesis of the Corpus Callosum (ACC)?
-Aicardi
- Apert
-Opitz
- Joubert
And others.
14Explain the prognosis of Agenesis of the Corpus Callosum (ACC).
Prognosis depends on high incidence of associated anomalies; may carry poor prognosis.
15Agenesis of the Corpus Callosum (ACC) is an isolated event. (True or False)
False
16Explain the symptoms or associations with Agenesis of the Corpus Callosum (ACC).
Agenesis of the Corpus Callosum (ACC) may be asymptomatic or associated with mental retardation and/or seizures.
17Explain the sonographic features of Agenesis of the Corpus Callosum (ACC).
Sonographic features:
* Absence of corpus callosum
* Elevation and dilation of third ventricle
* Widely separated lateral ventricular frontal horns with medial indentation of medial walls
* Dilated occipital horns ( colpocephaly ), giving lateral ventricles teardrop shape
* Absence of cavum septum pellucidum