1Term for the stoppage of bleeding or hemorrhage
Hemostasis
23 mechanisms for reducing blood loss
1 vascular spasm
2 platelet plug formation
3 blood clotting
3Which mechanism for reducing blood loss involves platelets binding to exposed collagen in blood vessel wall. Can stop bleeding from small blood vessel
Platelet plug adhesions
4Which mechanism for reducing blood loss involves Vasoconstriction? Vasoconstriction is due to damage to smooth muscle, substance released by activated platelets, reflexes stimulated by pain receptors.
Vascular spasms
5Step 1: in formation of clot; in formation of clot damaged tissue and platelets release factors that stimulate series of reactions that results in formation of this molecule
Damaged tissue and platelets release factors that stimulate series of reactions that result in formation of this molecule.
Formation of prothrombin activator (PTA)
6Step 2 in formation of clot: prothrombin is a plasma protein produced in liver
Prothrombin activator converts prothrombin into the enzyme thrombin
7Step 3 in formation of clot : fibrinogen is plasma proteins produced by liver
Thrombin converts soluble fibrinogens(in plasma) into insoluble fibrin
8Step 4 in formation of clot
Fibrin mesh traps cells to forma clot which strops blood flow
9Vitamin required for normal blood clotting. Fat soluble vitamin produced in large intestine. Dietary lipids needed for adequate absorption to prevent uncontrolled bleeding
Vitamin K
10Mineral essential for the clotting process
Calcium ions
11Term for dissolution of blood clots. Prevents clots from extending beyond site of damage and prevents small clots from becoming large clots
Fibrinolysis
12Plasma protein involved in clotting. This protein is an inactive enzyme.
Plasminogen
13Converts plasminogen to plasmin. Released when endothelium is damaged.
Tissue plasminogen
14Enzyme that digests fibrin and other substances that promote clotting.
Streptokinase(streptase)
15A antigen on RBC surface.
Type A blood & AB
16B antigen on RBC surface.
type B & AB
17Anti-A antibody in blood.
Type B & O
18Anti-B antibody in blood.
Type A & O
19Blood type that is universal donor
O
20Blood type that is universal recipient
AB
21True or False. Rh+ individual has Rh antigen on RBCs
true
22True or False. Normally, Rh- individuals do not have anti-Rh antibodies in blood
False
23Name for disease of newborn that occurs if Rh+ baby is born to Rh- mother with anti-Rh antibodies. Anti-Rh antibodies are present because blood from previous Rh+ child contacts mother’s blood during birth
Hemolytic disease of newborn(HDN)
24Loss of blood decreases blood volume Manifestations
Low BP
25Rupture of blood vessels and reduced clotting in GI tract (including mouth) or urinary tract. Manifestations
Blood in poop or pee
26Bleeding into joints. Causes swollen, red, painful joints
Manifestations
Hemarthrosis
27Vomiting blood
Manifestations
Hematemesis
28Decreased RBC count due to bleeding Manifestations
Anemia
29CNS hypoxia due to decreased blood flow and therefore oxygen to brain Manifestations
Faint and anxious
30Coughing up blood Manifestations
Hemoptysis
31Cardiac compensatory mechanism for low blood pressure
Manifestations
Rapid pulse
32Nosebleeds Manifestations
Repeated epistaxis
33Red or purple discolorations on skin that do not blanch when applying pressure. Due to bleeding from small blood vessels near surface of skin. Manifestations
Purpura
34Red or purple discolorations on skin that are less than 3 mm in diameter Manifestations
Petechiae
35Red or purple discolorations on skin that are greater than 1 cm in diameter. Manifestations
Ecchymosis