1are cylindrical shape and generally range from 5- 25g
medication sticks
2solid dosage forms intended for insertion into body orifices where they are melt or dissolve and exert local or systematic effects
suppositories
3nucous membrane of the rectum and vagina permit the absorption of many soluble drugs
systemic action
4it surrounds the colon receive the absorbed drug and initiate its circulation throughout the bodym bypassing the liver
lower hemorrhoidal veins
5factors of drugs absoption from rectal suppositories
ph and lack of buffering capacity of the rectal fluids, colonic content
6the form in which the drug is administered will not generally be chemically changed
ph and lack of buffering capacity of the rectal fluids
7rectal fluids is generally range from
7.2-7.4 ph
8administered and allowed to act before administration of a suppository
evacuation enema
9plays an important role in the release of the medication
suppository bases
10example of water soluble drug
cocoa butter
11irritation or inflammation is relieved-emollient or soothing, sppreading action
cocoa butter
12relesae more readily in glycerinated gelatin or polyethylene glycol
fat soluble drugs
13base used to prolong the release of the drug for several hours
alginic acid
14it is a type polymorphism
cocoa butter nf
15melts at 30 - 36 degrees celcius
cocoa butter nf
16it lowers the MP of cocoa butter
phenol and choral hydrate
17a solidifying agent
cestl ester wax (20%) or beeswax (4%)
18fat obtained from the roasted seed of
theobromna cocao
19melts at 34-35
cocoa butter