1RBCs, platelets, granulocytes, monocytes and macrophage lineage
What blood cells are produced by myeloid stem cells?
2bone marrow
What is considered myeloid tissue?
3lymphocytes
What blood cells are produced by lymphoid stem cells?
4nodes, thymus, spleen
What tissues are considered primary lymphoid tissue?
5eosinophils, neutrophils, basophils
What cells are considered granulocytes?
6NK cells, T-cells, B-cells
What cells are considered lymphocytes and derive from lymphoid stem cells?
7cytokines
What supports the growth factors used to control the growth and reproduction of different stem cells?
8relatively short (other than memory cells)
What is the life span of the WBC?
9leukopenia
Abnormally low white blood cell count
10neutropenia
deficiency of neutrophils
11granulocytopenia
a condition in which the number of granulocytes in the blood is lower than normal
12neonatal neutropenia, cyclic, kostmann syndrome
What are some congenital causes of neutropenia?
13Kostmann syndrome
a group of diseases that affect myelopoiesis, causing a congenital form of neutropenia (severe congenital neutropenia or SCN) usually without other physical malformations
14autoimmune, drug related, radiation therapy, hematologic malignancies
What are some causes of acquired neutropenia?
15bacterial or fungal infections (unable to fight infections)
What are the signs and symptoms of neutropenia?
16fever, generalized lymphadenopathy, sore throat, the appearance in the blood of atypical lymphocytes and several antibodies, hepatitis, anorexia, hepatosplenomegaly
What are the characteristic s/s of infectious mononucleosis?
17lymphomas, leukemias, multiple myeloma
What are the overarching categories of neoplastic disorders of hematopoietic and lymphoid origin?
18low grade, intermediate grade, high grade
What are the categories of non-hodgkin lymphomas?
19Burkitt and non-Burkitt lymphomas, immunoblastic (b-cell) and lymphoblastic (t-cell)
What are the types of high grade lymphomas?
20reed-sternberg cells
cells that are present in a biopsy of lymph node tissue r/t Hodgkin lymphoma
21no symptoms
What are symptoms present in stage A Hodgkin lymphoma?
22weight loss, fevers, pruritus, night sweats
What are the symptoms of stage B Hodgkin lymphoma?
23fatigue, anemia, involvement of liver, lungs, digestive tract, and CNS
What are the symtpoms of advanced stage Hodgkin lymphoma?
24arises in a single node or chain of nodes (usually above the diaphragm); reed-sternberg cells are present
What are the defining characteristics of Hodgkin lymphoma?
25originates at extranodal sites and spreads to anatomically contiguous nodes (usually retroperitoneum, pelvis, mesentery); reed-sternberg cells are NOT present
What are the defining characteristics of Non-Hodgkin lymphoma?
2618-30 yo
What age group is Hodgkin lymphoma most common in?
27retuximab
What drug is used for the treatment of non hodgkin lymphoma?
28leukemia
malignant neoplasms arising from the transformation of a single blood cell line (lymphoid or myeloid)
29leukemic cells
poorly differentiated blast cells that proliferate rapidly and have a long life span
30fatigue, pallor, weight loss, nosebleeds, repeated infections, easy bruising
What are the classic signs of acute leukemias?
31chronic leukemias have well-differentiated cells
What is the difference in cancer cells for acute and chronic leukemias?
32tumor lysis syndrome
life-threatening condition that occurs when large numbers of cancer cells are killed or damaged simultaneously and release their intracellular contents into the bloodstream causing metabolic and electrolyte disturbances
33multiple myeloma
a plasma cell dyscrasia characterized by expansion of a single clone of Ig producing plasma cells and a RESULTANT INCREASE IN SERUM LEVELS OF A SINGLE MONOCLONAL Ig or its fragments
34proliferation and activation of osteoclasts, pathologic fractures, pain, hypercalcemia
What are the s/s of multiple myeloma?
35osteoclasts
cells that break down bone