1Steps of General Adaptation Syndrome
Alarm: body reacts to stress
Resistance: parasympathetic branch of the ANS tries to counteract the changes the stressful stimulus caused and restore a state of homeostasis
Exhaustion: The body's resources have been depleted (chronic stress, which can cause hypertension, mild cognitive impairment, and depression)
2Benzodiazapines
less toxic than barbituates
cause GABA-A receptor activation
3short acting benzodiazapines
ATOM
Alprazolam
Triazolam
Oxazepam
Midazolam
4intermediate acting benzodiazapines
TLC
Temazepam
Lorazepam
Clonazepam
5long acting benzodiazepines
CDeF
Clorazepate
Clordiazepoxide
Diazepam
Flurazepam
6pregabalin (Lyrica) MOA
GABA analog, but does not act on GABA-A receptor. Instead inhbits voltage-dependent Ca channel (VDCC)
anxiolytic
7buspirone (BuSpar) MOA
5HT1A receptor agonist
D2 agonist
Not GABA - less sedation and side effects, slower response
anxiolytic
8Picrotoxin, Bicuculline
convulstant, GABA-A antgaonist
9Serotonin 5HT effect on anxiety
binding to 5-HT2A is anxiogenic (causes anxiety)
binding to 5-HT1a is anxiolytic (reduces anxiety)