CNS Depressants: Anxiety
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1
Steps of General Adaptation Syndrome
Alarm: body reacts to stress
Resistance: parasympathetic branch of the ANS tries to counteract the changes the stressful stimulus caused and restore a state of homeostasis
Exhaustion: The body's resources have been depleted (chronic stress, which can cause hypertension, mild cognitive impairment, and depression)
Resistance: parasympathetic branch of the ANS tries to counteract the changes the stressful stimulus caused and restore a state of homeostasis
Exhaustion: The body's resources have been depleted (chronic stress, which can cause hypertension, mild cognitive impairment, and depression)
2
Benzodiazapines
less toxic than barbituates
cause GABA-A receptor activation
cause GABA-A receptor activation
3
short acting benzodiazapines
ATOM
Alprazolam
Triazolam
Oxazepam
Midazolam
Alprazolam
Triazolam
Oxazepam
Midazolam
4
intermediate acting benzodiazapines
TLC
Temazepam
Lorazepam
Clonazepam
Temazepam
Lorazepam
Clonazepam
5
long acting benzodiazepines
CDeF
Clorazepate
Clordiazepoxide
Diazepam
Flurazepam
Clorazepate
Clordiazepoxide
Diazepam
Flurazepam
6
pregabalin (Lyrica) MOA
GABA analog, but does not act on GABA-A receptor. Instead inhbits voltage-dependent Ca channel (VDCC)
anxiolytic
anxiolytic
7
buspirone (BuSpar) MOA
5HT1A receptor agonist
D2 agonist
Not GABA - less sedation and side effects, slower response
anxiolytic
D2 agonist
Not GABA - less sedation and side effects, slower response
anxiolytic
8
Picrotoxin, Bicuculline
convulstant, GABA-A antgaonist
9
Serotonin 5HT effect on anxiety
binding to 5-HT2A is anxiogenic (causes anxiety)
binding to 5-HT1a is anxiolytic (reduces anxiety)
binding to 5-HT1a is anxiolytic (reduces anxiety)
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