1chemical structure or pharmacological action of drug
chemical group
2examples of chemical group drug classification
chemotherapeutic agents (antibiotics, cancer drugs)
pharmacodynamic agents (cholinergics, sedatives)
miscellaneous agents (narcotic analgesics, local anesthetics)
3specific biochemical interaction through which a drug
produces pharmacological effects
mechanism of action
4desired therapeutic effect
primary effect
5what the body does to the drug
pharmacokinetics
64 levels of pharmacokinetics
absorption
distribution
metabolism
excretion
7transfer of drug from site of administration, across membranes
and into the bloodstream (route, dosage, solubility)
absorption
8movement of drug to the body (receptor and acceptor sites)
distribution
9biotransformation (destructive, conjugation)
metabolism
10(kidneys, biliary secretion, lungs, sweat and saliva, mother’s milk)
excretion
11drug absorption fastest to slowest
solution
suspension
powder
capsule
tablet
coated tablet
enteric coated tablet
12effect of the drugs to the body
pharmacodynamics
13levels of pharmacodynamics
time course of drug effects
mechanism of drug action
dose-response relationship
biological variation response
14 onset of action
time course of drug effects
15 act on specific receptor sites (agonists,
antagonists); physical interference with cell function
mechanism of drug action
16efficacy and potency
dose-response relationship
17 therapeutic effect variation depending on age,
gender, pathological condition, psychological, tolerance, drug interactions
biological variation response
18No drug produces only 1 effect.
Toxic reaction (drug overdose)
side effect
adverse drug reaction
19adverse reaction or side effects
local irritation
allergies
20generic act of 1998 aka
ra 6675
21 Promote, require and ensure the production of an adequate supply,
distribution, use and acceptance of drugs and medicines identified by their
generic names
ra 6675enerics act of 1988
22Who shall Use Generic Terminology
• (a)(b)(c)(d)- all government agencies; medical, dental veterinary
practitioners; organization, company; drug outlets
ra 6675 section 6