1What drugs are in class 1A?
quinidine
procainamide
disopyramide
2What is the MOA of class 1A?
moderate blockage of Na+ channels
3What are the AE of quinidine?
QT prolongation
h/a
hearing/vision loss
tinnutus
psychosis and cognitive impairment (quinidine)
4What are the AEs of procainamide?
drug induced lupus erythematous
drug fever
5What are the AEs of disopyramide?
HF
anticholinergic effects
6What are the class 1B drugs?
lidocaine
mexiletine
7What are the AEs of the class 1B?
dizziness
nausea
AV block conduction
ventricular extrasystoles
8What is the MOA of class 1B?
weak blockage of Na+ channels
9What are the class 1C drugs?
flecainide
propafenone
10What are the AE of class 1C?
QT prolongation
proarrhythmogenic (CI after MI)
11What is the MOA of 1C?
strong blockage of Na+ channels
12What are the class 2 drugs?
beta blockers
13What are the AEs of beta blockers?
AV block
brady cardia
heart failure
hypoglycemia
hyperkalemia
dylipidemia
14When are the class 2 CI?
concurrent cocaine use
pheochromyocytoma
15What is the MOA of class 3?
potassium channel blocker
16What are the class 3 drugs?
amiodarone
dronedarone
sotalol
dofetilide
17What are the AEs of class 3?
QT prolongation
18What are the AEs of amiodarone?
HF, heart block, bradycardia hypotension
pulmonary fibrosis
thyroid dysfunction
liver dysfunction
neurologic side effects
19What is the MOA for class 4?
CCB- inhibit slow calcium channels
20What are the AE of verapamil and diltiazem (but less prominent)?
AV block
bradycardia
depression of sinus node
HF
constipation
flushing
edema
21What are the 5 medications in class 5?
adenosine
ivabradine
magnesium
digoxin
22What are the AE of adenosine?
flushing
SOB
chest burning
23what are the AE of ivabradine?
vision changes
bradycardia
hypotension
luminous phenomena
24What are the AE of magnesium? how does it work?
decreases calcium influx
hypotension
asystole
drowsiness
flushing
loss of reflexes
respiratory depression
25What are the AE of digoxin?
n/v
abdominal pain
blurry vision
yellow tint/halos