Antiarrhythmics
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1
What drugs are in class 1A?
quinidine
procainamide
disopyramide
procainamide
disopyramide
2
What is the MOA of class 1A?
moderate blockage of Na+ channels
3
What are the AE of quinidine?
QT prolongation
h/a
hearing/vision loss
tinnutus
psychosis and cognitive impairment (quinidine)
h/a
hearing/vision loss
tinnutus
psychosis and cognitive impairment (quinidine)
4
What are the AEs of procainamide?
drug induced lupus erythematous
drug fever
drug fever
5
What are the AEs of disopyramide?
HF
anticholinergic effects
anticholinergic effects
6
What are the class 1B drugs?
lidocaine
mexiletine
mexiletine
7
What are the AEs of the class 1B?
dizziness
nausea
AV block conduction
ventricular extrasystoles
nausea
AV block conduction
ventricular extrasystoles
8
What is the MOA of class 1B?
weak blockage of Na+ channels
9
What are the class 1C drugs?
flecainide
propafenone
propafenone
10
What are the AE of class 1C?
QT prolongation
proarrhythmogenic (CI after MI)
proarrhythmogenic (CI after MI)
11
What is the MOA of 1C?
strong blockage of Na+ channels
12
What are the class 2 drugs?
beta blockers
13
What are the AEs of beta blockers?
AV block
brady cardia
heart failure
hypoglycemia
hyperkalemia
dylipidemia
brady cardia
heart failure
hypoglycemia
hyperkalemia
dylipidemia
14
When are the class 2 CI?
concurrent cocaine use
pheochromyocytoma
pheochromyocytoma
15
What is the MOA of class 3?
potassium channel blocker
16
What are the class 3 drugs?
amiodarone
dronedarone
sotalol
dofetilide
dronedarone
sotalol
dofetilide
17
What are the AEs of class 3?
QT prolongation
18
What are the AEs of amiodarone?
HF, heart block, bradycardia hypotension
pulmonary fibrosis
thyroid dysfunction
liver dysfunction
neurologic side effects
pulmonary fibrosis
thyroid dysfunction
liver dysfunction
neurologic side effects
19
What is the MOA for class 4?
CCB- inhibit slow calcium channels
20
What are the AE of verapamil and diltiazem (but less prominent)?
AV block
bradycardia
depression of sinus node
HF
constipation
flushing
edema
bradycardia
depression of sinus node
HF
constipation
flushing
edema
21
What are the 5 medications in class 5?
adenosine
ivabradine
magnesium
digoxin
ivabradine
magnesium
digoxin
22
What are the AE of adenosine?
flushing
SOB
chest burning
SOB
chest burning
23
what are the AE of ivabradine?
vision changes
bradycardia
hypotension
luminous phenomena
bradycardia
hypotension
luminous phenomena
24
What are the AE of magnesium? how does it work?
decreases calcium influx
hypotension
asystole
drowsiness
flushing
loss of reflexes
respiratory depression
hypotension
asystole
drowsiness
flushing
loss of reflexes
respiratory depression
25
What are the AE of digoxin?
n/v
abdominal pain
blurry vision
yellow tint/halos
abdominal pain
blurry vision
yellow tint/halos
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