ANEMIA GENERAL OVERVIEW

Based on the provided notes on anemia, here is the complete, sequential set of flashcards following your strict formatting and content requirements.

Identify the condition defined as the decrease below normal of the number of red blood cells, hemoglobin, or volume of packed red cells.

Fill in the blank: The morphologic classification of anemias is based on ________ and MCHC.

Identify the morphologic classification where both MCV and MCHC are normal.

Enumerate three normocytic, normochromic conditions associated with a normal or decreased reticulocyte count.

Enumerate five normocytic, normochromic conditions associated with an increased reticulocyte count.

Identify the rare but potentially deadly bone marrow failure syndrome characterized by a decrease in the number of RBCs, WBCs, and platelets.

Identify the primary cause of aplastic anemia involving the depletion of specific cells.

Fill in the blank: Approximately 80% to 85% of aplastic anemia cases are classified as ________ aplastic anemia.

Identify the category of acquired aplastic anemia that has no known cause.

Enumerate three identified causes of secondary acquired aplastic anemia.

Identify the specific drug most frequently implicated in acquired aplastic anemia.

Enumerate two diseases associated with the 15% to 20% of inherited aplastic anemia cases.

Identify the most common inherited aplastic anemia which is also a chromosome instability disorder.

Enumerate three specific skeletal abnormalities associated with Fanconi Anemia.

Identify the specific skin pigmentation characteristic of Fanconi Anemia.

True or False: Fanconi Anemia is the same as Fanconi Syndrome.

Identify the condition also known as Marchiafava-Micheli Syndrome.

Enumerate the two specific complement regulatory proteins (and their CD numbers) that are deficient in PNH.

Fill in the blank: Without complement regulatory proteins, the body will ________ its own cells.

Enumerate three specific laboratory tests used for PNH diagnosis.

Identify the specific reagent used in flow cytometry for PNH that is a fluorescent labelled proaerolysin variant.

Identify the morphologic classification where both MCV and MCHC are low, showing small cells with increased central pallor.

Identify the specific deficiency that results in microcytic anemia by failing to maintain normal erythropoiesis.

Enumerate the conditions using the acronym CTAILS for microcytic, hypochromic anemias.

Identify the most common anemia among hospitalized patients, formerly known as ACD.

Identify the central feature of ACI characterized by decreased serum iron despite abundant iron stores.

Enumerate the three acute phase reactants (APRs) that contribute to ACI.

Identify the master regulatory hormone for systemic iron metabolism that controls ferroportin activation.

Identify the protein responsible for transporting iron from the tissues to the blood.

Identify the protein that specifically transports iron within the blood.

True or False: In Iron Deficiency Anemia (IDA), Serum Iron is low and TIBC is high.

Identify the condition where Serum Iron is high, TIBC is normal, and Serum Ferritin is high.

Identify the microcytic anemia where FEP (Free Erythrocyte Protoporphyrin) remains normal while Serum Ferritin is normal.

Identify the morphologic classification characterized by a high MCV and normal MCHC.

Enumerate three causes for Vitamin B12 deficiency.

Identify the specific cells in the stomach that produce HCl and Intrinsic Factor.

Identify the condition characterized by antibodies directed against parietal cells and intrinsic factor.

Identify the characteristic cell finding that is essentially pathognomonic for megaloblastic anemia.

True or False: Hypersegmented neutrophils are present in nonmegaloblastic anemia.

Identify the shape of macrocytes in megaloblastic anemia versus nonmegaloblastic anemia.

Identify the root cause of megaloblastic anemia involving DNA synthesis.

Identify the specific structure required for DNA synthesis that cannot be made without a methyl group from folate.

Identify the cofactor responsible for transferring the methyl group to methyl tetrahydrofolate.

Fill in the blank: If TTP cannot be made, it is replaced by ________ triphosphate.

Identify the scientific names for Vitamin B12 and Folate.

Identify the synthetic form of Vitamin B12 found only in supplements.

Identify the symptom described as the loss of epithelium on the tongue resulting in a smooth, sore surface.

Enumerate four neurologic symptoms unique to Vitamin B12 deficiency.

True or False: Vitamin B12 is destroyed by cooking.

Identify the specific diet group that is at risk for dietary Vitamin B12 deficiency.

Identify the potential fetal complication of folate deficiency during pregnancy.

True or False: Folates are heat labile and can lose nutritional value by overcooking.

Identify the specific diagnostic lab test result for folate deficiency involving Homocysteine.

Identify the specific diagnostic lab test result for Vitamin B12 deficiency involving Methylmalonic acid.

Identify the metabolically active form of Vitamin B12.