Geriatric Syndromes

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1
What are geriatric syndromes?
Common problems that affect older adults
o Frailty
o Delirium
o Falls
o Sleep disorders
o Dizziness
o Syncope
o Dysphagia
o Pressure ulcers
o Elder mistreatment
o Urinary Incontinence
Osteoporosis
2
Frailty
Associated with an increased risk of ...? (4)
Falls, disability, hospitalization and death
3
Frailty
Clinical syndrome where 3 or more of the following criteria are met ...?
- Unintentional weight loss (> 10 lbs over a year)
- Self-reported exhaustion
- Weakness (grip strength)
- Slow walking speed
- Low physical activity
4
Frailty
Difference between mild, moderate, and severe?
- Mildly frail = Limited dependence on others for instrumental activities of daily living
- Moderately frail = Help is needed with both instrumental and non-instrumental activities of daily living
- Severely frail = Completely dependent on others for the activities of daily living, or terminally ill
5
Frailty
What are the basic ADLs?
Basic self-care activities:
- Dressing
- Eating
- Ambulating
- Transfers
- Toileting/continence
- Hygiene
6
Frailty
What are the instrumental ADLs?
Needed to function independently in the community;
require physical + cognitive function
- Shopping
- Housework
- Accounting
- Food preparation
- Transportation
- Telephone use
7
What is considered a neurobehavioral manifestation of imbalances in the synthesis, release, and inactivation of neurotransmitters that normally control cognitive function, behavior, and mood?
Delirium
8
Delirium
Diagnostic criteria?
A) A disturbance in attention and awareness
- Reduced ability to direct, focus, sustain, and shift attention
- Reduced orientation to the environment
B) The disturbance:
- Occurs over a short period of time (usually hours to a few days)
- Represents a change from baseline attention and awareness, and
- Tends to fluctuate in severity during the course of a day.
C) An additional disturbance in cognition
- e.g., memory deficit, disorientation, language, visuospatial ability, or perception

Disturbances in Criteria A and C are not better explained by another preexisting, established, or evolving neurocognitive disorder and do not occur in the context of a severely reduced level of arousal, such as coma.
9
Delirium
Common causes?
· Hypoxia
· Dehydration
· Electrolyte disturbances
· Pain
· Medications
10
Medication-Induced Delirium
What classes have the highest risk?
- Anticholinergics
- Benzodiazepines
- Opioids

*Treat delirium by finding and reversing the underlying cause = NO treatment*
11
Delirium
T/F: Delirium is an independent marker for increased mortality during the 12 months after hospital admission
TRUE
12
Falls
What are the two types?
- Non-Syncopal: Unintentional events where the person comes to rest on the floor or ground that are NOT caused by loss of consciousness, stroke, seizure, or overwhelming force
- Syncopal: Fall caused by a transient, self-limited loss of consciousness
13
Falls
What is syncope? What is the reason it happens?
Transient, self-limited loss of consciousness usually leading to falling
- Rapid onset
- Spontaneous, complete, and prompt recovery

Caused by transient and sudden drop of cerebral oxygen delivery
- Due to altered cerebral autoregulation
14
Falls
What are the causes of syncope?
- Reflex syncopal syndromes = Vasovagal faint
- Orthostatic hypotension = **Medications**
- Cardiac arrhythmias
- Structural cardiac disease
- Cerebrovascular
15
Falls
T/F: Falls kill over 30,000 people annually.
TRUE
16
Falls
What are the strong evidence medication factors that lead to falls? (2)
- Psychoactive medication use
- Use of 4+ medications
17
Falls
When does falling become problematic?
When they cause an injury (mostly fractures)
18
Medication-Related Falls
Most common drugs associated with it?
· Any psychotropic
· Antipsychotic
· Sedatives/hypnotics
· Any benzodiazepine
· TCAs
· Type 1a anti-arrhythmic
· Digoxin
19
Fall Prevention Strategies
What are they?
- Adapt or modify home
- Withdraw or minimize harmful medications: Sedative/hypnotics, anxiolytics, antidepressants, antipsychotics
- Reduce the total number of medications (4+)
- Manage postural hypotension
- Treat foot problems
- Wear appropriate shoes
- Regular exercise
- Correct known vision problems
- Vitamin D supplement ≥ 800 units/day
20
Orthostatic Hypotension
Supine to standing reduction of ...?
SBP > 20 mmHg or DBP > 10 mmHg
21
Orthostatic Hypotension
Symptoms?
Dizziness / Postural unsteadiness / Syncope / Falls
22
Orthostatic Hypotension
Causes?
- Volume depletion
- Baroreflex dysfunction
- Autonomic insufficiency
- Venodilators: α-blockers / α-β blockers
23
Orthostatic Hypotension
Non-pharmacologic management?
- Rise slowly from sitting or supine position
- Cross legs while standing and contract muscles for 30 seconds
- Raise head of bed by 20-30 degrees
- Use waist high compression stockings
- Increase sodium and water intake (except in HF patients)
** Goal of non-pharm therapy is to increase venous return to the heart**
24
Orthostatic Hypotension
Pharmacologic treatment?
- Discontinue causative medications
- Fludricortisone: 0.1 mg daily starting dose / 0.3 mg daily maximum
- Midodrine: 2.5 mg TID starting dose / 10 mg TID maximum
25
Sleep Disturbances
As people age, what sleep disturbances happen?
- Take longer to fall asleep
- Have lower sleep efficiency
- Have more nighttime awakenings
- Wake up earlier than they would like
- Require more daytime naps
26
Insomnia
What is the main complaint in older adults?
Low quantity and/or poor quality of sleep resulting in a sense of non-restorative sleep
27
Insomnia
Drugs that can cause this?
28
Insomnia Tx
Non-pharm treatment?
Sleep hygiene
- Check effect of medications on sedation/wakefulness
- Avoid caffeine, alcohol, and cigarettes after lunch
- Limit liquids in the evening
- Keep a regular bedtime/wake schedule
- Avoid naps or limit to one per day, no longer than 30 minutes
29
Insomnia Tx
If hypnotics are prescribed, how should they be used in geriatric patients?
- Always be accompanied by behavioral interventions
- Prescribe the lowest effective dose
- Use hypnotics with shorter half-lives
30
Insomnia Tx
Recommended Zolpidem dose in geriatrics?
5 mg IR or 6.25 mg CR
31
What are the considerations to using medications in dysphagia?
- Have patient swallow medications while fully upright if possible
- Change medications to liquids or powders which can be taken on top of food
- Be knowledgeable about which medications can be crushed
32
What are areas of local tissue trauma developing where soft tissue is compressed between a bony prominence and external surface for a prolonged period?
Pressure Ulcers
33
Pressure Ulcers
How do we treat?
Prevention is the best treatment!
- Reposition every two hours
- Manage incontinence
Debridement: Necessary for Stage III-IV ulcers
Occlusive, moisture-retaining dressing: Key for Stage I-II ulcers
Appropriate analgesia for dressing changes
Maximize nutrition
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