Primary Hemostasis

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1
Innermost coat of the blood vessel wall, lined by simple squamous epithelium, is known as
Tunica intima (tunica interna)
2
Middle layer of the blood vessel wall, composed of smooth muscle and elastic fibers, is the
Tunica media
3
Thickest coat among the three blood vessel wall layers is the
Tunica media
4
Outermost coat of the blood vessel wall, composed of fibrous connective tissue containing autonomic nerve endings and vasa vasorum, is called
Tunica adventitia (tunica externa)
5
Small networks of blood vessels in the tunica adventitia that supply nutrients to the vessel wall tissue are termed
Vasa vasorum
6
Average diameter size of distributing blood vessels that leave the heart (arteries) is
4 mm
7
Vessels possessing the thickest walls of the vascular system are
Arteries
8
Microscopic continuation of arteries (30 µm size) that branch into metarterioles and join capillaries are
Arterioles
9
Average diameter size of collecting blood vessels that return blood to the heart (veins) is
5 mm
10
Vessels characterized by having a larger and more irregular lumen than arteries are
Veins
11
Microscopically sized veins (20 µm size) connecting capillaries to veins are
Venules
12
Smallest blood vessels (8 µm size) through which blood passes from the arterial to the venous system are
Capillaries
13
Thinnest walled and most numerous blood vessels in the vascular system are
Capillaries
14
Epithelial layer composition of capillaries allowing rapid material transport is
Single cell layer of simple squamous epithelium
15
Specialized types of capillaries located in the bone marrow, spleen, and liver are called
Sinusoids
16
Alternative chemical name for Prostacyclin is
Prostaglandin I2 (PGI2)
17
Primary physiological action of Prostacyclin (PGI2) on platelets is
Inhibits platelet activation
18
Metabolic pathway responsible for producing Prostacyclin in endothelial cells is
Eicosanoid pathway
19
Receptor on the platelet membrane to which Prostacyclin penetrates and binds is
IP receptor
20
Metabolic product of ATP and ADP released from endothelial cells that stimulates vasodilation is
Adenosine
21
Function of Thrombomodulin (TM) in relation to thrombin activity is
Serves as a thrombin cofactor
22
Effect of Thrombomodulin binding to thrombin on the clotting process is
Reduces thrombin's ability to participate in the clotting process
23
Complex formed by thrombomodulin and thrombin directly activates
Protein C and TAFI
24
Activated Protein C (APC) functions functionally in hemostasis by
Inactivating Factors Va and VIIIa
25
Full name for TAFI activated by the thrombomodulin-thrombin complex is
Thrombin activatable fibrinolysis inhibitor
26
Endothelial surface glycosaminoglycan that weakly enhances Antithrombin (formerly Antithrombin III) is
Heparan sulfate
27
Primary function of Tissue Plasminogen Activator (TPA) in the fibrinolytic system is
Major plasminogen activator
28
Enzyme resulting from the conversion of plasminogen by TPA, which dissolves blood clots, is
Plasmin
29
Primary functional roles of von Willebrand Factor (VWF) in primary and secondary hemostasis are
Acts in platelet adhesion and carries/protects Factor VIII
30
Cellular sites responsible for the synthesis of von Willebrand Factor (VWF) are
Endothelial cells and megakaryocytes
31
Storage organelle for VWF within endothelial cells is the
Weibel-Palade bodies
32
Storage organelle for VWF within platelets is the
Alpha granules
33
Full formal definition name of ADAMTS-13 enzyme is
A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13
34
Common functional alias given to ADAMTS-13 is
VWF-cleaving protease
35
Primary organ that secretes the plasma enzyme ADAMTS-13 is
Liver
36
Physiological mechanism by which ADAMTS-13 regulates circulating VWF size is
Cleaving ultra-long VWF multimers (ULVWF) into shorter, less hemostatically active segments
37
Hematologic disorder caused directly by a deficiency of ADAMTS-13 enzyme is
Thrombotic Thrombocytopenic Purpura (TTP)
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