LEC 10 BIOL 431
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1
What is the humoral immune response?
B cells in the body fluid kill bacteria, bacterial toxins, viruses
2
What is the activation/ clonal selection? AKA Primary Immune Response
Activation = antigen binding to specific receptor
Clonal selection = phagocytosis of B cell> stim cloning of selected receptors
Clonal selection = phagocytosis of B cell> stim cloning of selected receptors
3
What 2 cell line are created from the primary immune response
4
What is the purpose of the memory B cells?
To store the antigen receptor in the event teh body ever sees the same antigen
Stored in the spleen, lymph node and lymph tissue
Stored in the spleen, lymph node and lymph tissue
5
What is the purpose of the Plasma B Cells?
To produce antibodies
6
How long does it take to create the first plasma and memory B cells?
(primary immune response)
(primary immune response)
10-14 days
7
What happens during re-exposure?(secondary immune response)
stim mitosis of plasma cells = Increase antibodies
takes 2-3 days to see in titers
takes 2-3 days to see in titers
8
What are the 4 modes of action for antibodies?
Complimenatry fixation
neutrilization
agglutination
precipitation
neutrilization
agglutination
precipitation
9
What is the complimentary fixation mode of action for antibodies?
Ab binds to bacteria allowing compliment protein chance to punch hole in membrane leading to lysis
10
What is the neutrilization mode of action for antibodies?
Blocks receptors sites on bacteria, toxins, and viruses therefore it can’t bind to host cells
11
What is the agglutination mode of action for antibodies?
Clumping of several bacterial cells by antibodies binding to multiple antigen
12
What is the precipitation mode of action for antibodies?
Similiar to agglutination but for viral particles
13
What is the IgG ?
Immunoglobulin G
80% of antibodies
can cross blood vessels and PLACENTA
attacks bacteria, virus , toxins
80% of antibodies
can cross blood vessels and PLACENTA
attacks bacteria, virus , toxins
14
What is the IgM?
5-10% of antibodies
1st to react
in blood
activates compliment system
1st to react
in blood
activates compliment system
15
What is IgA?
10-15% of antibodies
secretory
Found in Saliva , Milk, Sweat, mucus
secretory
Found in Saliva , Milk, Sweat, mucus
16
What is IgD?
.2% representing cell surface receptors on memory b Cells
17
What is IgE?
.002% of antibodies
receptors on mast and basophils
=histamine response
receptors on mast and basophils
=histamine response
18
What is the function of the T4 helper cells?
T4 recognizes Class II MHC protein on APC > trigger lymphokine release > causes mitosis of plasma B cell and memory B cells > activates T8 cells
19
What is the purpose of teh T8 Cells?
T8 cells will recognize class I MHC protein on body cells, if antigen is present T8 will destroy cell