LEC 10 BIOL 431

B cells in the body fluid kill bacteria, bacterial toxins, viruses

Activation = antigen binding to specific receptor
Clonal selection = phagocytosis of B cell> stim cloning of selected receptors

To store the antigen receptor in the event teh body ever sees the same antigen
Stored in the spleen, lymph node and lymph tissue

To produce antibodies

10-14 days

stim mitosis of plasma cells = Increase antibodies
takes 2-3 days to see in titers

Complimenatry fixation
neutrilization
agglutination
precipitation

Ab binds to bacteria allowing compliment protein chance to punch hole in membrane leading to lysis

Blocks receptors sites on bacteria, toxins, and viruses therefore it can’t bind to host cells

Clumping of several bacterial cells by antibodies binding to multiple antigen

Similiar to agglutination but for viral particles

Immunoglobulin G
80% of antibodies
can cross blood vessels and PLACENTA
attacks bacteria, virus , toxins

5-10% of antibodies
1st to react
in blood
activates compliment system

10-15% of antibodies
secretory
Found in Saliva , Milk, Sweat, mucus

.2% representing cell surface receptors on memory b Cells

.002% of antibodies
receptors on mast and basophils
=histamine response

T4 recognizes Class II MHC protein on APC > trigger lymphokine release > causes mitosis of plasma B cell and memory B cells > activates T8 cells

T8 cells will recognize class I MHC protein on body cells, if antigen is present T8 will destroy cell