Tuberculosis (TB)

Mycobacterium tuberculosis

-acid fast bacilli
-grows in filaments or clumps
-non-motile
-aerobic
-slow growing (more than 16 hrs per cycle)

Humans

Respiratory tract

airborne (direct transmission, respiratory droplets, latent infections)

2-10 weeks

*colonization of alveoli and resident macrophages
*cells spread infection to lymph nodes, lungs, and other tissues
*immune response results in granulomas, possible necrosis and cavity formation

-cough
-chronic fever
-poor appetite
-weight loss
-weakness
-extra symptoms depend on affected tissues

-permanent tissue damage
-mortality (80% for XDR strain)

consumption

-avoid exposure
-get tested if at risk
-wear protective filters around those with active infections
-vaccination

-Anti-Tuberculosis Drugs

-First line 4 drug treatment
-Second Line

-Isoniazid
-Ethambutol
-Pyrazinamide
-Rifampicin

-Aminoglycosides
-fluoroquinones