1Disease Classification of Strep Throat?
Pharyngitis
2Classification of Streptococcus pyogenes?
*gram positive cocci
*group A strep (carbohydrate structure)
*numerous virulence factors (exotoxins)
*150 types (strains or serotypes)
*Betahemolytic
*non motile
*catalase neg
3Streptococcus Pyogens gram pos or neg?
gram positive cocci (stains purple, one membrane, thick cell wall)
4Virulence factors of Streptococcus pyogens?
*exotoxins
5How many strains or serotypes?
150
6What is Streptococcus pyogens response to blood agar?
*betahemolytic (RBC's completly destroyed or lysed and surronding medium loses opactity)
7Motile or non-motile?
*non-motile
8Streptococcus response to catalase test?
*negative (no bubbles)
9Reservoir of strep throat?
*human skin and respiratory tract
10What percentage of school children are reservoirs for streptococcus pyogens?
15-20%
11Portal of entry?
mouth and sinuses
12Mode of transmission?
*direct contact-with infected individuals
*indirect-inhaled droplets, contaminated food or surfaces
13Incubation period?
2-5 dys
14Pathogenesis of Strep throat? clue "Friends can't marry gators"
*colonization of tissue (virulence factors assist)
*protein F facilitates attachment
*capsule and M proteins inhibits phagocytosis
*protein G inhibits antibody binding
*secreted enzymes damage tissue
15Symptoms?
*sore and inflammed throat
*fever
*headache
*fatigue
*children may experience (nausea, vomiting, abdominal pain)
16When do symptoms resolve?
3-7 dys
17What are not symptoms of Strep throat?
*cough
*runny nose
*hoarseness
*conjuctivitis (pink eye)
18Complications of Strep throat?
*Scarlet fever
*Cellulitis (tissue damage or abscess)
*Metastatic infection
*Streptococcal toxic shock syndrome
*post streptococcal glomerulonephritis
*acute rheumatic fever
19Physical indications of scarlet fever?
*red diffuse rash that spreads from head, neck, and trunk to extremeties
*strawberry tongue
20What is acute glomerulonephritis?
*immune complexes in kidney nephron lead to inflammatory respone (lead to permanent damage to kidneys
21Characteristics of Rheumatic fever? When do they occur after onset of pharyngitis?
*inflammatory lesions involving the hearts, joints, subcutaneous tissue and CNS
*1-5 wks post pharyngitis
22What are minor manifestations of Rheumatic fever?
*fever
*swollen or painful joints
23What are major manifestations of rhematic fever?
*carditis
*arthritis
*Chorea (abnormal involuntary movements)
*subcutaneous nodules
*erythema marginatum (pink rings on torso)
24How long do untreated symptoms of rheumatic fever last?
3-6 months
25complications of acute rheumatic fever?
Secondary rheumatic heart disease (permanent damage to heart valves, congestive heart failure, accounts for 233,000 deaths/yr
26How to prevent strep throat aquisition?
*avoid crowded areas and infected individuals
*practice good hygiene
27Treatment for Strep Throat?
*Penicillin (PCN) or Amoxicillin
*Analgesics for pain
28Affect of PCN or amoxicillin?
reduces duration of symptoms by 1 dy, can prevent immune complications