1fatty acid transport into the mitochondria
fatty acyl coa has to combine with carnitine in order to become fatty acyl carntine but the CoA gets cleaved off in order to attach carnitine
2fatty acid after transport into mitochondria
fatty acyl carnitine gets broken down and turned into fatty acyl coA and carnitine carnitine goes back out
3free fatty acids going through beta-oxidation which produces
1 FDAH
1NADH
Acetyl Coa
Cost
1ATP
4where is the ATP used
the first step of beta oxidation
when you have to add the Coa on the fatty acid
5Acetyl CoA enters TCA cycle to produce
10ATP
6with beta oxidation you get how many ATP
4 becuase you get NADH and FADH which goes through the ETC
7how mnay ATP produce depends on how many carbons lings the fatty acid is
example if you have a 16 long
then you are going through 7 rounds of beta oxidation and you have 7X4=28
then you are going through 8 acetyl coA so you have 8X 10=80
108 all together and then 107 with the cost
8ETC occurs where
in the inner mito membrane
9ETC overview
has 4 complexes
create proton gradient in the intermembrane space
10complex 1
have NADH dump H into it
oxidazes NADH
pump 4 H from matrix to intermembrane space
passes e to CoQ
11complex 2
oxidzes FADH
doesnt add H to the intermembrane space
passes e to CoQ
12complex 3
receives e from the CoQ
becomes charged pump 4 H into intermembrance space
passes e to the cyto C
13complex four
hydrolyzes oxygen to form H2O (enzyme is Cytochrome oxidase)
pump 4 H into the intermembrane space
14ATP synthase
forms ATP
energy from proton gradient is used to form ATP
15from 1 NADH we get
10 H
2.5 ATP
16from 1 FADH we get
6 H
1.5 ATP
17ATP yield
32 if glusoce
33 if glyogen
18at rest skeletal muscle accounts for
up tp 20% of CO
during exercise more than 80% of CO to skeletal muscle
19blood shunting
vasodilation is to muscle and skin
vasoconstriction is to everything else
heart stays the same
20skeletal muscle pump
venous blood flow doesnt have the pressure from the pump so uses the muscles to ump blood back up tot he heart
has a valve so that the blood cant rush back down
21what is no contraction
then bloood will pool and you will pass out becuase of lack of blood to the brain
22McArdle's disease
symtpoms
-muscle cramps
-musle pain muslce damage discolaortion in the urine
-fatigued easily with actitvy
-second wind phenonomon (when aerboic kicks in)
treatment
-no cure
-high fat diet
-timing of digestion
-safe exercise planning
what is it
-bascially you cant break down glyocgen dont have the enzyme for it
23isometeric force
load: fixed
muscle ends: fixed
contraclie ends: shortened
elastic elements: stretched
24isotomic intially
load: fixed
muscle ends: fixed
contractile elements: shortening
elastic elements: stretch
25isotonic in EE=load
load: moving
musce ends: shortenting so joint angle decreases
contractlie elements: shortening
elastic elements: constant
26differnce with eccentric isotonic
occurs when the muscle is lengthened
joint angle increases