1OH SHIPP
Sulfasalazine
Hydralazine
Isoniazid
Phenytoin
Procainamide
2voclosporin brand name
Lupkynis
3voclosporin (Lupkynis) mechanism
calcineurin inhibitor (supress immune system by inhibiting T-lymphocyte activation)
4voclosporin (Lupkynis) when to use?
In compbination with corticosteroids and MMF or other immunosupressive agent
5belimumab brand name
Benlysta
6belimumab (Benlysta) mechanism of action
Monoclonal antibody (B-lymphocyte stimulator)
7belimumab (Benlysta) ROA
SubQ or IV
8belimumab (Benlysta) when to use?
On top of other therapy
9anifrolumab brand name
Saphnelo
10anifrolumab (Saphnelo) MOA
Monoclonal antibody (inhibits type 1 interferon receptor)
11anifrolumab (Saphnelo) ROA
IV
12Anticholinergic properties (Anti-SLUD)
Salivation
Lactrimation
Urination
Defecation
Can't see, can't pee, can't spit, can't shit
13What can be applied frequently in order to reduce ocular symptoms of Sjogren's Syndrome
Artificial tears
14Topical immunosuppresive used for Sjogren's Syndrome
Cyclosporine eye drops (restasis and cequa)
15Non-pharmacological treatment for dry mouth
The main one is hydration. A Flouride hydrating toothpase such as Biotene and sugar-free gums and hard candies can also help.
16Pharmocological treatment for dry mouth
Pilocarpine (Salagen) and Cevimeline (Evoxac)
17Pilocarpine brand name
Salagen
18Pilocarpine (Salagen) MOA
muscarinic agonist
19cevimeline brand name
Evoxac
20cevimeline (Evoxac) MOA
ACH derivative, with a greater affinity for muscarinic receptors of the lacrimal and salivary tissue