1Carbamazepine genetic susceptibility
HLA-B associated with Stevens Johnson Syndrome
2Lamotrigine genetic susceptibility
HLA-B associated with Stevens Johnson Syndrome
3Abacavir genetic susceptibility
HLA-B associated with abacavir hypersensitivity
4Type 1 clinical manifestations and timing
urticaria, anaphylaxis, can occur in minutes to hours
5Type II clinical manifestations
anemia, cytopenia, thrombocytopenia
6Type III clinical manifestations and timing
vasculitis (vein inflammation), fever, rash, arthralgia (joint pain), occurs 1-3 weeks after drug exposure.
7Type IV clinical manifestations, timing, and mechanism
T cell mediated, shows contact sensitivity, skin rashes, organ and tissue damage, occurs 2-7 days after drug exposure.
8Common causes of urticaria/angiodema
antibiotics
9Common causes of SJS/TEN
sulfonamides, anticonvulsants, allopurinol
10Common causes of Type II reaction
heparin, IIb/IIIa inhibitors (do not rechallenge!)
11common causes of hemolytic anemia
ceftriaxone, cefotetan, NSAIDS, zosyn
12common causes of DRESS
anticonvulsants, antibiotics, allopurinol
13common causes of pseudoallergic (anaphylactoid) reactions
opioids, vancomycin
14what should be given to patient's experiencing anaphylaxis and are on a chronic beta-blocker
glucagon