Medical Terms

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1
Idiosyncratic reaction
we don't know why this reaction occurred
2
Anaphylaxis
Severe allergic reaction with hives, tongue or throat swelling, shortness of breath. Epinephrine is an antidote and diphenhydramine (Benadryl) and/or corticosteroids are usually helpful
3
Agonist
a drug stimulates a receptor causing an effect
4
Antagonist
a drug blocks another drug or natural chemical from stimulating a receptor preventing an effect
5
Partial agonist/antagonist
a drug that blocks another drug from stimulating a receptor but inherently stimulates it itself produces a slight effect.
6
Pharmacokinetic drug interaction
One drug changing the drug concentrations (Cmax, AUC) of another drug. Pharmacokinetic is ADME (Absorption, Distribution, Metabolism, Elimination)
7
Pharmacodynamic drug interaction
One drug accentuates (potentiates) or attenuates (antagonizes) another drug's effect without changing the Cmax or AUC of another drug.
8
Cytochrome P450 System
System that metabolizes many drugs in the liver (and small intestine). Creates active or inactive metabolites.
9
Off Label
Drug being used for a purpose other than the FDA approved indication.
10
Therapeutic Range/Window
the concentrations between the minimum effective and minimum toxic concentration.
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