lesson 1 part 2
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1
chemical structure or pharmacological action of drug
chemical group
2
examples of chemical group drug classification
chemotherapeutic agents (antibiotics, cancer drugs)
pharmacodynamic agents (cholinergics, sedatives)
miscellaneous agents (narcotic analgesics, local anesthetics)
pharmacodynamic agents (cholinergics, sedatives)
miscellaneous agents (narcotic analgesics, local anesthetics)
3
specific biochemical interaction through which a drug
produces pharmacological effects
produces pharmacological effects
mechanism of action
4
desired therapeutic effect
primary effect
5
what the body does to the drug
pharmacokinetics
6
4 levels of pharmacokinetics
absorption
distribution
metabolism
excretion
distribution
metabolism
excretion
7
transfer of drug from site of administration, across membranes
and into the bloodstream (route, dosage, solubility)
and into the bloodstream (route, dosage, solubility)
absorption
8
movement of drug to the body (receptor and acceptor sites)
distribution
9
biotransformation (destructive, conjugation)
metabolism
10
(kidneys, biliary secretion, lungs, sweat and saliva, mother’s milk)
excretion
11
drug absorption fastest to slowest
solution
suspension
powder
capsule
tablet
coated tablet
enteric coated tablet
suspension
powder
capsule
tablet
coated tablet
enteric coated tablet
12
effect of the drugs to the body
pharmacodynamics
13
levels of pharmacodynamics
time course of drug effects
mechanism of drug action
dose-response relationship
biological variation response
mechanism of drug action
dose-response relationship
biological variation response
14
onset of action
time course of drug effects
15
act on specific receptor sites (agonists,
antagonists); physical interference with cell function
antagonists); physical interference with cell function
mechanism of drug action
16
efficacy and potency
dose-response relationship
17
therapeutic effect variation depending on age,
gender, pathological condition, psychological, tolerance, drug interactions
gender, pathological condition, psychological, tolerance, drug interactions
biological variation response
18
No drug produces only 1 effect.
Toxic reaction (drug overdose)
side effect
Toxic reaction (drug overdose)
side effect
adverse drug reaction
19
adverse reaction or side effects
local irritation
allergies
allergies
20
generic act of 1998 aka
ra 6675
21
Promote, require and ensure the production of an adequate supply,
distribution, use and acceptance of drugs and medicines identified by their
generic names
distribution, use and acceptance of drugs and medicines identified by their
generic names
ra 6675enerics act of 1988
22
Who shall Use Generic Terminology
• (a)(b)(c)(d)- all government agencies; medical, dental veterinary
practitioners; organization, company; drug outlets
• (a)(b)(c)(d)- all government agencies; medical, dental veterinary
practitioners; organization, company; drug outlets
ra 6675 section 6
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