1Drugs EXTENSIVELY bound (>90%)
monitor to know how much is active and dont give at same time with other high PPB drugs - if given with a drug that competes for ppb it will become less bound, this will have more of the drug in circulation which can have negative effects
2Oral anticoagulants
Warfarin (Coumadin)
3oral antidiabetics
glimepiride, glipizide, glyburide
4lipid lower drugs
gemfibrozil, statins
5NSAID
indomethacin, phenylbutazone, ibuprofen, naproxen, diflunisal, diclofenac
6Loop Diuretics
Furosemide (Lasix)
7Antihypertensives
diazoxide, losartan
8Anti Infectives
ceftriaxone, nalidixic acid, ketoconazole, itraconazole, suramin, nelfinavir
9Benzodiazepines
diazepam, midazolam
10Others:
montelukast, zafirlukast, entacapone, leflunomide