Drug - Pharmacodynamics

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1
Drugs EXTENSIVELY bound (>90%)
monitor to know how much is active and dont give at same time with other high PPB drugs - if given with a drug that competes for ppb it will become less bound, this will have more of the drug in circulation which can have negative effects
2
Oral anticoagulants
Warfarin (Coumadin)
3
oral antidiabetics
glimepiride, glipizide, glyburide
4
lipid lower drugs
gemfibrozil, statins
5
NSAID
indomethacin, phenylbutazone, ibuprofen, naproxen, diflunisal, diclofenac
6
Loop Diuretics
Furosemide (Lasix)
7
Antihypertensives
diazoxide, losartan
8
Anti Infectives
ceftriaxone, nalidixic acid, ketoconazole, itraconazole, suramin, nelfinavir
9
Benzodiazepines
diazepam, midazolam
10
Others:
montelukast, zafirlukast, entacapone, leflunomide
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