1Natural Penicllins
Non-beta lactamase producing Gram(+) Cocci
- Strep
- Entero (s)
Spirochete
- Treponema Pallidum (syphilis)
2Penicillinase-Resistant
Bad against
- Gram(-)
- Anaerobes
Used for
- MSSA
3Aminopenicillin
Extended Spectrum
Good for Penumonococci & Streptococci
D.O.C for Sus. Enterococus
Gram (-) NSHEPS
4Gram(-) non-beta lactamase producing bacteria
N.Meningitidis
Salmonella
H.Flu
E.Coli
P.Mirabilis
Shigella
5Monobactams
Similar to spectrum to 3rd Gen. Cephalosporin
Gram (-) aerobes only
61st Gen.
Gram (+) cocci, except MRSA
Gram (+) anaerobic bacteria (except B.fragilis)
Ineffective to Proteus, Enterobacter, Serratia, Salmonella, H.Flu, Pseudomonas
Moderate activity against some Gm-rods (Klebsiella and E.coli)
72nd Gen
Gram (+), Some Gram (-)
Same as 1st Gen. Plus!
H. influenzae
M. catarrhalis
N. meningitidis
N. gonorrhoeae
83rd Gen.
Mainly Gram (-) Enterobacter, Serratia, Proteus, E. coli, H. influenza
Moderate against pseudomonas
Less active against Gm (+) cocci than 1st or 2nd Gen.
94th Gen.
Gram (-) aerobes including P. aeruginosa, Enterobacter aerogenes, Enterobacter cloacae
1st gen + 3rd gen spectrum (very broad)
105th Gen.
Gram (+), MRSA, MSSA, Streptococcus, GNRs
Less gram negative activity than 4th generation cephalosporins
11Monobactams
similar spectrum to 3rd gen cephalosporin (Gmaerobes only)
12Glycopeptides
Gm (+) aerobes (Staph including methicillin-resistant, Enterococcus, Strep including PCN-resistant)
Gram (+) anaerobes (Clostridium/C. dif)
13Cyclic Lipopeptides
Gm+ aerobes (MRSA, vancomycin-resistant E.faecium, E. faecalis)
14Flouroquinolones
Good Staph
Moderate Strep
Great Gram (-) aerobes (H. flu, P.aeruginosa, Enterobacter, Shigella, Salmonella)
- atypical organisms (Mycobacterium)
15Macrolides
Gram (+)
Gram (-) (H. flu)
- genital pathogens (N. gonorrhoeae, Chlamydia trachomatis, Treponema pallidum - syphilis)
16Tetracyclines
No Calcium!
Gram (+) & Gram (-)
- bacteriostatic
- better drugs exist so most offten used for minor infections (skin & soft tissue; acne)
17Metronidazole
Gram (+) & Gram (-) anaerobes
Trichomonas vaginalis, Giardia lamblia
bactericidal
18Clindamycin
Gram (+) & Gram (-) aerobes
Gram (+) & Gram (-) anaerobes
Protozoa (Toxoplasma & Plasmodium)
19SMX-TMP
Gram (+) & Gram (-) aerobes
Chlamydia
Protozoa
20Aminoglycosides
Powerful Gram (-)
21Fidaxomicin
Exclusively for C. diff