Glomerulonephritis

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1
What is GIomerulonephritis?
inflammation of the glomeruli
2
Acute Primary Causes? Chronic
Infection
♡ Bacteria: streptococcus, sepsis, klebsiella pneumoniae
♡ Viruses: dengue fever, varicella, parvovirus, hep B & C, HIV
3
Acute Secondary Causes?. o o
Systemic
♡ lupus, chronic liver conditions (Hep B & C), autoimmune hepatitis, cirrhosis
♡ nephropathy, vasculitis, HIV associated G.
4
Chronic Causes?
Sometimes Unknown
Infection
Inflammation
Impaired renal perfusion
5
Signs & Symptoms
Lethargy / Irritation
Pallor
Headaches
N/V
AB / Flank pain
Anorexia
Edema - periorbital, generalized, pulmonary
6
Urinary Manifestations
  • decreased urine output
  • Dysuria
  • Hematurin
7
Diagnosis
  • Urinalysis : hematuria, proteinuria
  • Microsopic examination of the urine : Dysmorphic erythrocytes, RBC cell cast, epithelial cast
  • 24 hoururine collection : qauntify protein excretion rate → increased to 500mg - 3g / 24hrs
8
Both A & C
Increased creatinine & BUN
9
To identify the cause?
  • Immunological pannel
  • CT-Scan of abdomen : structure abnormalities
10
Report to HCP
signs of fluid over load
11
Symptoms of uremia
severe fatigue, N/V, ALOC
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