Malaria

Malaria- protozoan disease of the blood

Plasmodium; P. falciparum

Eukaryote; protozoa, obligate intracellular parasite, nonmotile, complex multi host life span

Humans and Mosquitos

Skin- circulatory system

Mosquito Bite- Vector Female Anopheles mosquito; vertical, lantent infection

1-5 weeks

Protozoans replicate in human hepatocytes (liver cells). Cells lyse and release of next protozoa stage causes inflammation and fever. Protozoa replicate in RBCs causes cellular damage and adhesion to vasucular surfaces. Ruptured RBC is associated with inflammation, fever, anemia, and depriving tissue of O2

Cycles of flue like symptoms (more severe version); fever, chills, tiredness, nausea/vomitng, headache, and diarrhea

Anemia, Jaundice, seizures, coma, kidney failure, relapse (P. vivax and P. ovale), mortality (429k-731k)

limit contact with mosquitos: avoiding traveling to areas where malaria is endemic, insecticides, barriers- protective clothing or nets, repellents- DEET, GM Mosquito; Vaccine (not very effective- 30%); Prophylaxis

When you take the treatment drug in order to avoud contracting the diease; ex. for malaria you would use Ant-malaria drugs such as Chloroquine

Mefloquine, Chloroquine, quinine and doxycycline