Ide-cel
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1
CAR-T stands for
Chimeric antigen Receptor - t cell
2
what's "chimeric" in a chimeric antigen receptor t-cell ?
the antigen receptor contains elements from both antibodies and t cell receptors
3
What does "chimeric" mean
made of many different parts
4
what are "antigen receptors"
protein receptors on a surface of a cell that targets a specific substance
5
what is the significance of chimeric antigen receptors on a T cell
Allows the patient's T-cell to target a specific antigen found on patient's cancer
6
What does LVV stand for
Lentiviral vector
7
PBMC stands for
peripheral blood mononuclear cell
8
what does peripheral blood mononuclear cell mean
blood cells with a round nucleus
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What do PBMC's consist of?
Platelets
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Examples of Lymphocytes?
T cells
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Examples of Myeloid cells?
Dendritic cells
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Ex-vivo means
occuring outside the human body
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autologous means:
To be of patient's own cells
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BCMA stands for
B cell maturation antigen
15
what kind of cancer is multiple myeloma
cancer of the plasma cells
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what happens when someone has cancer of the plasma cells
body makes too many plasma cells and too many antibodies
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What do B cells do
develop into plasma cells when antigens are present
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what is leukapheresis
the gathering of patient cells from blood
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Where does leukapheresis take place
in a clinic
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How long does apheresis take?
4 hours
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When does BMS receive the patient's bag of cells?
After apheresis
22
What is the general process of Ide-cel manufacturing?
Bulk Media Prep
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What is Day -1
PBMC Isolation & PBMC Cryopreservation
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What is Day 0
PBMC Thaw & Culture initiation
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What is Day 1
LVV Transduction
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What is Day 2
48 hour incubation
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What is Day 3-9
Static Culture Maintenance and Expansion
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What is Day 10
Drug Product Harvest
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Is ide-cel an aseptic process or sterile process?
Aseptic
30
Drug Product Harvest is which day
Day 10
31
Drug Harvest Cryopreservation is which day
Day 10
32
Static Culture Maintenance and Expansion is which day
Day 3-9
33
48 hour incubation is which day
Day 2
34
LVV Transduction is which day
Day 1
35
PBMC Thaw & Culture initiation is which day
Day 0
36
PBMC isolation is which day
Day -1
37
PBMC Cryopreservation is which day
Day -1
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