Ide-cel
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1
CAR-T stands for
Chimeric antigen Receptor - t cell
2
what's "chimeric" in a chimeric antigen receptor t-cell ?
the antigen receptor contains elements from both antibodies and t cell receptors
3
What does "chimeric" mean
made of many different parts
4
what are "antigen receptors"
protein receptors on a surface of a cell that targets a specific substance
5
what is the significance of chimeric antigen receptors on a T cell
Allows the patient's T-cell to target a specific antigen found on patient's cancer
6
What does LVV stand for
Lentiviral vector
7
PBMC stands for
peripheral blood mononuclear cell
8
what does peripheral blood mononuclear cell mean
blood cells with a round nucleus
9
What do PBMC's consist of?
Platelets
10
Examples of Lymphocytes?
T cells
11
Examples of Myeloid cells?
Dendritic cells
12
Ex-vivo means
occuring outside the human body
13
autologous means:
To be of patient's own cells
14
BCMA stands for
B cell maturation antigen
15
what kind of cancer is multiple myeloma
cancer of the plasma cells
16
what happens when someone has cancer of the plasma cells
body makes too many plasma cells and too many antibodies
17
What do B cells do
develop into plasma cells when antigens are present
18
what is leukapheresis
the gathering of patient cells from blood
19
Where does leukapheresis take place
in a clinic
20
How long does apheresis take?
4 hours
21
When does BMS receive the patient's bag of cells?
After apheresis
22
What is the general process of Ide-cel manufacturing?
Bulk Media Prep
23
What is Day -1
PBMC Isolation & PBMC Cryopreservation
24
What is Day 0
PBMC Thaw & Culture initiation
25
What is Day 1
LVV Transduction
26
What is Day 2
48 hour incubation
27
What is Day 3-9
Static Culture Maintenance and Expansion
28
What is Day 10
Drug Product Harvest
29
Is ide-cel an aseptic process or sterile process?
Aseptic
30
Drug Product Harvest is which day
Day 10
31
Drug Harvest Cryopreservation is which day
Day 10
32
Static Culture Maintenance and Expansion is which day
Day 3-9
33
48 hour incubation is which day
Day 2
34
LVV Transduction is which day
Day 1
35
PBMC Thaw & Culture initiation is which day
Day 0
36
PBMC isolation is which day
Day -1
37
PBMC Cryopreservation is which day
Day -1
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