Adrenal D/O

All adrenocortical hormones are steroid compounds derived from ______

Three main hormones of the adrenal cortex are _______, _____, & _____

Aldosterone Promotes ______ and _______. Without aldosterone, the kidney loses excessive amounts of _____ an _____

Aldosterone also affects _______ absorption in the ______, especially the ______

Signs and Symptoms of Mineralocorticoid (aldosterone) Deficiency

Signs and Symptoms of Mineralocorticoid (Aldosterone) Excess

Cortisol release is controlled by the secretion of _____ by the _____ gland, which is controlled by _______ hormone secreted by the ______

CRH, ACTH, and cortisol secretory rates peak in in the ______; and trough in the ______

Cortisol stimulates ______ in the _____ and decreases ____ use in the body; leading to ____; Inhibits _____ & stimulates catabolism of _____; has _____ effects; and decreases _____ & _____

Signs and Symptoms of Glucocorticoid (Cortisol) Deficiency

Signs and Symptoms of Glucocorticoid (Cortisol) Excess

The adrenal cortex continually secretes several male sex steroid hormones (androgens) including ______, ______, _______, ______ that are converted to _____; Androgen release is stimulated by _____

Congenital Adrenal Hyperplasia (CAH) is a ______ genetic condition that leads to decreased or absent ______ function in the _______ leading to abnormal ______

Addison's Disease is an _____ Disease Characterized by decreased or absent production of one or all three groups of adrenal steroid hormones.

Signs and symptoms of Addison's Disease typically develop slowly and include

Long Term Effects of Steroids

Primary adrenal insufficiency is when there’s a problem with the adrenal glands themselves. As a result, both _____ & ____ production is deficient

Secondary adrenal insufficiency is when theres a problem with the _______ gland, which secretes insufficient ______

ACTH regulates _____ production

Tertiary adrenal insufficiency is when there's a problem that originates with the _____ and there’s insufficient _____ secretion

CRH stimulates the ____ to release ____

Cortrosyn Stimulation Testing for ______ diagnosis; Cosyntropin is a synthetic _____; Allows assessment of ______ production under physiological stress

Cortrosyn Stimulation Testing procedure includes baseline labs- _____ & _____; Cortrosyn injection- _____ & ______; Repeat labs- _____ & _____ minute

Cortrosyn Stimulation Testing is also used to diagnose ______ in various adrenal conditions

CAH treatment includes replacement of _____, ______, and _______ as needed

Treatment Goals of Congenital Adrenal Hyperplasia (CAH) include

Adrenoleukodystrophy is an _________ genetic disorder caused by a _______, resulting in Elevated plasma and tissue concentrations of _______; leading to the progressive loss of ________, and the degradation of the ________

Because Adrenoleukodystrophy is an X-linked disorder, it primarily affects _____

Adrenoleukodystrophy is diagnosed with a blood test that detects _______ and a genetic test

Adrenoleukodystrophy treatment includes _______ & _________

Morning (8AM) Fasting Cortisol level: at least ____

Stress dose steroids = Hydrocortisone _____ mg/m2/day divided _____

Solu-Cortef Injection for management of acute adrenal crisis= _______ mg Hydrocortisone given IM

Cushing’s syndrome is a metabolic disease resulting from ______ production; Characterized by the body's inability to _____

Cushing’s syndrome is UNUSUAL IN _____ & ______

Cushing’s syndrome is caused by ______ or ______

24-Hour Urine Free Cortisol is the ________ for cushing syndrome; It is a direct reflection of ______ in the blood

Dexamethasone is a high-potency oral steroid, given to ________

_____ are the study of choice for the Adrenal Glands

Pituitary Radiation is _____ line therapy for pituitary adenoma ; Side effect seen in > 80% of patients is ______

In young children, 80% of Cushing syndrome is caused by a unilateral ________ tumor; They're often ______

Pheochromocytoma is a Rare childhood tumor that originates in the ______ , that causes the overproduction of _______

Peak Incidence for a Pheochromocytoma is ____ to _____ years of age

Clinical Manifestations of a Pheochromocytoma= "Five Hs":

Which is the most appropriate way to monitor whether a patient with Addison disease is receiving the correct amount of mineralocorticoid?

Most common form of CAH causes