1Why is therapeutic drug monitoring used with cefepime?
3x higher trough levels on average in patients who experienced neurotoxicity
2Dosing for obesity
Choose dosing on the higher end, or extended infusions
note that vancomycin uses a lower dose for obese patients
3Ideal body weight formula
50+2.3 for every inch over 5 feet (45 for women)
4AjdW formula (used for obese patients in cockrauf gault)
IBW + 0.4*(ABW-IBW)
5BMI Formula
kg/m^2
obese is greater than 30
6What are the bacteriostatic antibiotics?
Macrolides
Tetracyclines
7What antibiotics are concentration dependent?
Aminoglycosides
Fluoroquinolones
Want 10:1 peak:MIC
8Why is tobramycin prefered over gentamycin
Higher potency, so giving at the same dose will be more effective, higher peak:MIC
9target time>MIC for beta lactams for less severe infections and severe infections
>50% for less severe
100% for severe