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Biologic DMARDs

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1
Why use a Biologic DMARD?
More side effects and more expensive, however they are used if nonbiologic treatment fails (30-50% of patients) or they are unable to use nonbiologic treatment. Usually only used for established RA.
2
adalimumab brand
Humira
3
adalimumab class
anti-TNF human mAb
4
adalimumab ROA
SQ
5
certolizumab pegol brand
Cimzia
6
certolizumab pegol class
pegylated anti-TNF human mAb
7
certolizumab pegol ROA
SQ
8
etanercept brand
Enbrel
9
etanercept class
anti-TNF receptor protein
10
etanercept ROA
SQ
11
golimumab brand
Simponi
12
golimumab class
anti-TNF human mAb
13
golimumab ROA
SQ or IV
14
infliximab brand
Remicade
15
infliximab class
anti-TNF chimeric mAb
16
infliximab ROA
IV
17
abatacept brand
Orencia
18
abatacept class
recombinant CTLA4 fusion protein
19
abatacept ROA
IV
20
rituximab brand
Rituxan
21
rituximab class
anti-CD20 chimeric mAb
22
rituximab ROA
IV
23
tocilizumab brand
Actemra
24
tocilizumab class
IL6 human mAb
25
tocilizumab ROA
IV
26
sarilumab brand
Kevzara
27
sarilumab class
IL6 human mAb
28
sarilumab ROA
SQ
29
tofacitinib brand
Xeljanz
30
tofacitinib class
JAK inhibitor
31
tofacitinib ROA
PO
32
baricitinib brand
Olumiant
33
baricitinib class
JAK inhibitor
34
baricitinib ROA
PO
35
upadacitinib brand
Rinvoq
36
upadacitinib class
JAK inhibitor
37
upadacitinib ROA
PO
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