1Identify the test used to differentiate HS that can be corrected with either glucose or ATP.
Autohemolysis test.
2True or False: Green top tubes contain the anticoagulant Heparin.
True.
3Identify the result of the Osmotic Fragility Test (OFT) in cases of Hereditary Spherocytosis (HS).
Increased osmotic fragility.
4Fill in the blank: The ________ binding test is a confirmatory test for HS using flow cytometry.
EMA.
5Identify the term for polychromatophilic erythrocytes which are larger than normal red cells with a bluish tinge.
Diffusely basophilic erythrocytes.
6Identify the substance responsible for the bluish tinge in polychromatophilic RBCs.
Residual RNA.
7Identify three conditions associated with large numbers of polychromatophilic RBCs.
1-Decreased RBC survival, hemorrhage, or erythroid hyperplastic marrow.
8Fill in the blank: In the grading of polychromasia, a percentage of 1% is graded as ________.
Slight.
9Fill in the blank: A polychromasia percentage of 3% corresponds to a grade of ________.
1
11Fill in the blank: A polychromasia percentage of 5% corresponds to a grade of ________.
2
13Fill in the blank: A polychromasia percentage of 10% corresponds to a grade of ________.
3
15Fill in the blank: A polychromasia percentage of
11% corresponds to a grade of ________.
17Identify the term used to describe an increased number of red cells with variation in shape.
Poikilocytosis.
18Identify the RBC that is almost spherical in shape and lacks central pallor.
Spherocyte.
19Enumerate four conditions associated with spherocytes.
1-Hereditary spherocytosis, autoimmune hemolytic anemia, burns, and ABO HDN.
20True or False: Spherocytes may be wrongly reported if the feathered edge of the blood film is examined.
True.
21Identify the RBC also known as a "Mouth Cell" that has a slit-like central pallor.
Stomatocyte.
22Enumerate four conditions associated with stomatocytes.
1-Rh Deficiency Syndrome, Alcoholism, Electrolyte Imbalance, and Severe liver diseases.
23Identify the dehydrated form of a stomatocyte that appears "puddled" at one end.
Xerocyte.
24Identify the RBC also known as a Thorn or Spur cell characterized by an irregularly spiculated surface.
Acanthocyte.
25Fill in the blank: Abetalipoproteinemia is also known as ________ syndrome.
Bassen-Kornzweig.
26Enumerate the three substances NOT found in the plasma of patients with Abetalipoproteinemia.
1-VLDL, LDL, and chylomicron.
27Identify the RBC also known as Echinocytes characterized by a regularly spiculated surface.
Burr cell.
28Identify the condition characterized by a marked increase in plasma urea and waste products where Burr cells are commonly seen.
Uremia.
29Identify the RBC shape described as oval-shaped or "eggs."
Elliptocyte.
30Identify the condition also known as Southeast Asian Ovalocytosis.
Hereditary Ovalocytosis.
31Enumerate four conditions where elliptical or cigar-shaped RBCs are seen.
1-Hereditary Elliptocytosis, Hb C disease, Iron deficiency anemia, and Pernicious anemia.
32Identify the RBC also known as a Teardrop cell.
Dacryocyte.
33Enumerate three characteristics of Primary Myelofibrosis (PMF) found in the marrow or blood.
1-Splenomegaly, marrow fibrosis, and presence of dacryocytes.
34Identify the term for fragmented RBCs also known as Schizocytes.
Schistocyte.
35Identify the specific bacteria serotype associated with Hemolytic Uremic Syndrome (HUS).
Escherichia coli serotype 0157:H7.
36Identify the group of disorders characterized by RBC fragmentation and thrombocytopenia.
MAHAS.
37Enumerate the four major disorders classified under MAHAS.
1-TTP, HELLP, HUS, and DIC.
38Identify the helmet-shaped schistocyte that may appear in MAHA.
Helmet cell.
39Fill in the blank: DIC is also known as ________ syndrome or consumption coagulopathy.
Defibrination.
40Identify the specific test used for DIC.
D-dimer test.
41Enumerate the six causes of DIC using the acronym TOMASA.
1-Tissue trauma, Obstetric complications, Mucus-secreting tumors, Acute infections, Snake bites, and Acute promyelocytic leukemia.
42Identify the RBC also known as Sickle cells or Menisocytes.
Drepanocyte.
43Identify the form of drepanocyte that is crescent-shaped with long projections and cannot return to its original shape.
Irreversible sickle cell.
44Identify the form of drepanocyte that has less pronounced projections and can return to a biconcave shape.
Oat-shaped cells.
45Identify the RBC also known as a Codocyte, Platycyte, or Leptocyte.
Target cell.
46True or False: Codocytes show a centrally stained area with a thin outer rim of hemoglobin.
True.
47Identify the enzyme deficiency associated with the presence of codocytes.
LCAT deficiency.
48Identify the RBC also known as a Degmacyte that resembles a bite mark.
Bite cell.
49Identify the condition associated with the presence of Bite cells.
G-6-PD deficiency.
50Identify the folded RBCs associated with Hemoglobin SC disease.
Biscuit cell.
51Identify the RBC with bipolar or central distribution of hemoglobin seen in Sickle cell anemia.
Bronze Elliptocyte.
52Identify the large, pale-pink staining "ghost" of a red cell frequently seen in malaria.
Semilunar body.
53Identify the content of Basophilic Stippling, also known as Punctate Basophilia.
Aggregated RNA.
54Identify the condition also known as plumbism or saturnism associated with coarse basophilic stippling.
Lead poisoning.
55Identify the RBC inclusion also known as Pappenheimer bodies.
Siderotic granules.
56Identify the staining reaction used to confirm the presence of iron in Siderotic granules.
Prussian blue reaction.
57Identify the peripheral blood picture characterized by both normochromic and hypochromic RBCs in Sideroblastic Anemias.
Dimorphic.
58Identify the RBC inclusion composed of remnants of nuclear chromatin (DNA).
Howell-Jolly bodies.
59True or False: Howell-Jolly bodies are Feulgen reaction positive.
True.
60Identify the organ responsible for removing Howell-Jolly bodies via macrophages.
Spleen.
61Identify the RBC inclusion described as purple-blue loops or rings which are remnants of the mitotic spindle.
Cabot rings.
62Identify the inclusion composed of denatured and precipitated hemoglobin visualized only with supravital stains.
Heinz bodies.
63Identify the inherited condition resulting from sensitivity to fava beans that presents with Heinz bodies.
Favism.
64Identify the abnormal hemoglobin composed of four beta globin chains.
Hb H.
65Identify the characteristic appearance of RBCs containing Hb H bodies when stained with supravital stain.
Pitted golf ball.
66Identify the inclusion associated with Malaria that may present with Schuffner's dots.
Protozoan parasites.
67Identify the parasitic infection associated with the "Maltese Cross" appearance.
Babesia spp.
68Enumerate four conditions associated with the presence of Spherocytes.
1-Hereditary spherocytosis, autoimmune hemolytic anemia, burns, and ABO HDN.
69Fill in the blank: Stomatocytes are frequently associated with Alcoholism and ________ Deficiency Syndrome.
Rh.
70Identify the condition, also known as Hereditary Xerocytosis, characterized by the presence of xerocytes.
Dehydrated hereditary stomatocytosis.
71Identify the specific disease, also known as Bassen-Kornzweig Syndrome, associated with Acanthocytes.
Abetalipoproteinemia.
72True or False: McLeod Syndrome and Pyruvate kinase deficiency are associated with the presence of Acanthocytes.
True.
73Identify the condition characterized by renal insufficiency and waste product imbalance that presents with Burr cells.
Uremia.
74Enumerate five conditions associated with the presence of Elliptocytes.
1-Hereditary Elliptocytosis, Hb C disease, Iron deficiency anemia, Pernicious anemia, and Thalassemia.
75Identify the specific anemia also known as Mediterranean Anemia or Hereditary Leptocytosis.
Thalassemia.
76Identify the form of cancer, previously called agnogenic myelofibrosis, associated with Teardrop cells.
Primary Myelofibrosis (PMF).
77Enumerate four conditions classified as Microangiopathic Hemolytic Anemias (MAHAs) where Schistocytes are found.
1-TTP, HELLP, HUS, and DIC.
78Identify the specific bacterial infection associated with HUS and RBC fragmentation.
Escherichia coli serotype 0157:H7.
79Identify the two primary conditions associated with the presence of Drepanocytes.
1-Sickle cell anemia and Hemoglobin SC disease.
80Fill in the blank: Target cells are commonly associated with Hemoglobinopathies, Thalassemia, and ________ disease.
Liver.
81Identify the enzyme deficiency associated with the formation of Bite cells or Degmacytes.
Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.
82Identify the specific disease associated with the presence of Biscuit cells.
Hemoglobin SC disease.
83True or False: Bronze elliptocytes are associated with Sickle cell anemia.
True.
84Identify the infection frequently associated with the presence of Semilunar bodies.
Malaria.
85Identify the metal poisoning, also known as plumbism, associated with coarse Basophilic stippling.
Lead poisoning.
86Fill in the blank: Basophilic stippling is seen in ________ deficiency and anemias with impaired hemoglobin synthesis.
Pyrimidine-5-nucleotidase.
87Identify the anemia characterized by a dimorphic peripheral blood picture where Siderotic granules are found.
Sideroblastic Anemias.
88Identify two conditions besides thalassemia where Siderotic granules may be observed.
1-Hemochromatosis and Hemosiderosis.
89Enumerate three conditions associated with the presence of Howell-Jolly bodies.
1-Megaloblastic anemias, After splenectomy, and Thalassemia.
90Identify the three conditions associated with the presence of Cabot rings.
1-Megaloblastic anemias, Refractory anemia, and Lead poisoning.
91Identify the condition resulting from sensitivity to fava beans that causes the formation of Heinz bodies.
Favism.
92Identify the hemoglobin variant disease, a subtype of alpha thalassemia, where Hb H inclusion bodies are seen.
Hb H Disease.
93Identify the parasitic infection associated with the presence of Schuffner's dots.
Malaria.
94Identify the parasitic infection associated with the "Maltese Cross" formation in RBCs.
Babesia spp..
Would you like me to create another set focusing specifically on the staining methods and laboratory descriptions used for these inclusions?