1What are the 5 functions of the skeletal system?
Support, Protection, Movement, Hematopoiesis, and Mineral Storage.
2How does the skeletal system protect the organism?
There are bones around the brain (skull bones) that protect it from non-traumatic injury, as well as bones around the heart and lungs (thoracic cage) that protect them.
3What is hematopoiesis?
The process of creating red blood cells (RBC) and white blood cells (WBC).
4What are the two types of bone marrow?
Red Bone Marrow (RBM) and Yellow Bone Marrow (YBM).
5What does red bone marrow do?
RBM creates blood cells. It is where hematopoiesis takes place.
6What does yellow bone marrow do?
YBM stores fat.
7Where can red bone marrow be found? (Which specific bones?)
RBM can be found in the skull, thoracic cage, spine, and pelvis.
8Where can yellow bone marrow be found? (Which specific bones?)
YBM can be found in the extremities; all of the bones that make up the arms, legs, hands, and feet.
9Children are born having bones that have only...
- Yellow Bone Marrow
- Red Bone Marrow
10At what age do humans have all of their yellow bone marrow developed?
25 years old.
11What is an osteogenic cell? What is the function of an osteogenic cell?
An osteogenic cell is a stem cell. An osteogenic cell eventually develops into an osteoblast.
12What is an osteoblast? What does an osteoblast have the potential to turn into?
An osteoblast is a cell that forms bones (they lay down bone matrix and collagen fibers [osteoid tissue]). Osteoblasts will eventually develop into osteocytes.
13What is an osteocyte?
An osteocyte is a mature bone cell.
14What is an osteoclast? What is their purpose.
An osteoclast is a cell that destroys bone. They break down bone in the process of bone remodeling, and they also release calcium.
15What bone type has an epiphysis and diaphysis?
The long bones.
16What part of the bone is the epiphysis?
The ends of the long bone.
17What part of the bone is the diaphysis?
The mid section of the long bone.
18What is articular cartilage?
It is hyaline cartilage that covers the epiphysis of long bones.
19An epiphyseal line is the ossified remains of what? What was the purpose of the original structure?
The epiphyseal plate. The purpose was to facilitate growth of bones in childhood development.
20Where can the medullary cavity be found?
In the mid section of the bone, the core in other words. (Also described as being located in the diaphysis.)
21What are the 7 main structures of compact bone?
Osteons, bone lamellae, osteocytes, lacunae, canaliculi, central canals, and perforating canals.
22What is an osteon?
A unit of compact bone.
23What is the bone lamellae? What does it contribute to the compact bone?
The bone lamellae are concentric layers of compact bone. They creates a strong bone that is against bending or breaking.
24What is a lacuna?
This is where osteocytes live within the bone matrix.
25What is a canaliculi? What is its purpose?
They are little tunnels between the Lacunas, for the osteocytes to be able to communicate amongst themselves.
26What passes through central and perforating canals?
Blood vessles and nerves.
27What is spongey bone composed of?
They are composed of weaved layers of trabeculae.
28What is stored in the trabeculae of spongey bone?
Osteocytes.
29What passes through the gaps of the trabeculae within spongey bone?
Red bone marrow and blood vessles.
30What is the periosteum of the bone?
The periosteum forms the outer surface of the bone.
31What is the endosteum of the bone?
The endosteum lines the inner surface of the medullary cavity.
32Which direction of bone growth is interstitial growth?
It is growth in length.
33Which direction of bone growth is appositional growth?
It is growth in width.
34In interstitial growth, where does the growth occur at originally?
The epiphyseal plate.
35What are the 4 main stages of interstitial growth?
Reserve, proliferation, maturation/hypertrophy, and calcification.
36Define: Chondrocytes
Produces and maintains the cartilaginous matrix. Essentially produces cartilage.
37Define: Proliferation
Chondrocytes are dividing via mitosis.
38Define: Maturation/Hypertrophy
Chondrocytes are expanding rapidly which makes the bone expand.
39What happens to get to the stage of a "calcified matrix"?
Chondrocytes die and osteoblasts replace them with a bony matrix.
40What is the purpose of calcium homeostaisis?
To regulate the amount of calcium in the blood stream.
41What hormone is released when calcium levels DROP? What is the osteoclast response?
Parathyroid is the hormone released. Osteoclasts begin releasing more clacium into the blood stream.
42What hormone is released when calcium levels RISE? What is the osteoclast response?
Calcitonin is the hormone released. This hormone inhibits the osteoclasts from releasing calcium.
43Where does calcitonin come from?
The thyroid glands.
44A patient comes in with a prior diagnosis of Osteoporosis. What is the result of this disease in the bones and how could you expect for this to manifest in the patient's life?
Osteoporosis causes the compact bone to be less dense, which will manifest as brittle bones. The patient my often have fratures or breaks.
45What are the 4 stages of a frature repair?
A hematoma forms, a callus is formed from cartilage, the cartilage of the callus is replaced by trabecular bone, remodeling occurs.
46What is intramembranous ossification?
It is when bone develops from mesenchymal tissue (a type of embryonic connective tissue).
47Why type of bones are formed from intramembranous ossification?
This forms the flat bones, which are bones of the skull pelvis, sternum. And it also forms the clavicles.
48What are the basic steps to intramembranous ossification? There are about 10 steps.
Mesenchymal Cells group into clusters -> Forms osteoblasts -> Creates ossification centers -> Osteoblasts make osteoid tissue -> Forms trabeculae and makes a woven pattern intertwined around blood vessels -> Osteoid tissue traps osteoblasts -> Creates more osteocytes -> Matrix ossifies -> Compact bone develops around the trabeculae (spongy bone) -> The blood vessles in the trabeculae develops into red bone marrow.
49What is endochondral ossification?
It is when bone slowly replaces hyaline cartilage that is found in the epiphyseal growth plate of bones. All of the other bones are formed this way.
50What are the steps to endochondral ossification? There are about 12.
Mesenchyme cells -> Osteoblasts -> Creates the bony collar -> Bony collar restricts blood flow to chondrocytes -> Chondrocytes die and break down -> Blood vessles invade the cavity -> Osteogenic cells enter the cavity -> Osteoblasts replace the chondrocytes with a matrix to form spongey bone -> Osteoclasts will break down and form the medullary cavity -> Blood vessels will enter the ends of the long bones which makes the secondary ossification center -> Osteoblasts will lay down spongy bone (middle to outside)-> Hyaline cartilage remains around the ends of the bone which makes articular cartilage and remains in the epiphyseal plate.