AD 3

MOA: a cholinesterase inhibitor, inhibits both
butyrylcholinesterase and acetylcholinesterase

Excretion: Mainly via urine (97% as metabolites); faeces (0.4%)

Prescribed for moderate to severe disease:

– blocks the actions of glutamate at NMDA receptor sites.

● Theorized to protect the neurons from further damage
(Neuroprotective)
● 100% bioavailability of all dosage forms
● Minimally subject to drug interactions involving CYP450
isozymes; however, drug clearance
● decreased by alkaline urine by as much as 80%

is a non-competitive N-methyl-D-aspartate (NMDA)-
receptor antagonist which binds preferentially to NMDA-
receptor-operated cation channels.

● for moderate to severe disease
● neuroprotective agent

Excretion: Mainly via urine (approx 57-82% as unchanged
drug). Terminal half-life: 60-100 hr

○ patient w/ CV disease, epilepsy, history of convulsions or
those w/ predisposing factors for epilepsy.
○ Moderate to severe renal and severe hepatic impairment.
○ Pregnancy and lactation.

Inc Ach (Donepezil) + block Glutamate (Memantine) =

(medical term for bruise / pasa)

is a fatty acid found in processed coconut oil. The
human body breaks down caprylic acid into the protein ketone.

is proven that it can help w/ memory of px w/ AZD

A similar protein is used in a drug called .

Caprylic acid is a fatty acid found in processed coconut oil. The
human body breaks down caprylic acid into the protein ketone.

regular consumption of omega-3 fatty acids reduced cognitive impairment.

is an alternative medicine that is believed to promote self-
healing by using fine, sterile needles.

This therapy is thought to stimulate the body and improve the
flow of energy.

● enhances mood and memory
● use of essential oils

gingko biloba may benefit people with cognitive impairment
caused by AD