1What is causative agent of Pseudomonas infection?
Pseudomonas aeruginosa
2What type of microorganism is Pseudomonas aeruginosa?
*gram negative (size is 1 x 1-5 micro meters)
*facultative aerobe
3What are special characteristics of Pseudomonas aeruginosa?
*antibiotic resistance
*biofilms
4Epidemiology of Pseudomonas aeruginosa?
Reservoir: ubiquitous (animals and their enviornment)
*Portal of entry: compromised tissues
*transmission: indirect and direct transmission, nosocomial infections
5Incubation period of Pseudomonas aeruginosa?
hours to days (variable)
6Pathogenesis of Pseudomonas aeruginosa?
*bacterium attaches to and colonizes surfaces using flagella and pilli
*secretes effector proteins (virulence factors) that disrupts tissues and cells
*Exotoxin A inhibits translation
*Proteases digest tissues and inhibit clot formation
*phospholipase digest cell membrane
*toxin pyocyanine produces greenish color at site of infection
7Signs and Symptoms of Psuedomonas aeruginosa?
*skin lesions with green pus
*chills
*fever
*varies on location (folliculitis, green nail syndrom, keratitis, UTI. pneumonia)
8Complications of Psuedomonas aeruginosa
*spread of infectino to other organs
*bacteremia
*sepsis
*necrotizing lesions
9What is mortality for bacteremia
12-60%
10Treatment for Psuedomonas aeruginosa?
*antibiotics (multidrug-resistant variants)
11How To prevent Psuedomonas aeruginosa?
*disinfection of surfaces and equipment
*proper aseptic technique
*proper wound care and removal of dead tissue