COVID-19
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1
Coronaviruses are enveloped (DNA/RNA) viruses.
RNA
2
Human coronaviruses typically cause ___________________________ and may cause ___________________________ infections.
common colds and lower respiratory tract infections
3
In 2019, a novel coronavirus labeled SARS-CoV-2 spread, causing much more severe respiratory illness than its predecessors. The disease resulting from SARS-CoV-2 is called ________________.
COVID-19
4
What is the preferred test for COVID-19 detection?
Nucleic acid amplification test (PCR) from upper respiratory tract (nasopharyngeal, nasal, or oropharyngeal)
5
What populations are at higher risk for progressing to severe COVID-19?
- Age > 65
- T2D
- Respiratory disease
- Cancer
- Renal disease
- Obesity
- Sickle cell anemia
- Pregnancy
- Transplant/Immunosuppressed
- T2D
- Respiratory disease
- Cancer
- Renal disease
- Obesity
- Sickle cell anemia
- Pregnancy
- Transplant/Immunosuppressed
6
COVID-19
Common symptoms:
Common symptoms:
- Fever
- Chills
- Muscle pain
- Loss of taste/smell
- Sore throat
- SOB
- Fatigue
- HA
- Chills
- Muscle pain
- Loss of taste/smell
- Sore throat
- SOB
- Fatigue
- HA
7
COVID-19
Prevention:
Prevention:
- Vaccine
- Mask/Distancing
- Monoclonal antibodies (pre-exposure or post-exposure prophylaxis_
- Mask/Distancing
- Monoclonal antibodies (pre-exposure or post-exposure prophylaxis_
8
When should Evushield (tixagevimab/cilgavimab) be used?
Age ≥ 12 who do NOT have COVID-19 and are not eligible for vaccination for health reasons
9
Majority of patients infected with COVID-19 will have only mild symptoms and will not require treatment (True/False_
True
10
COVID-19
Outpatient Management:
Outpatient Management:
- OTC antipyretic/analgesic/antitussive
- Adequate rest & fluid consumption
- Paxlovid (for outpatients who are at risk of progressing to severe illness)
- Adequate rest & fluid consumption
- Paxlovid (for outpatients who are at risk of progressing to severe illness)
11
Outpatients may receive these antiviral therapies if they are at risk of progressing to severe illness:
- *Paxlovid* (nirmatrelvir/ ritonavir)
- Veklury (remdesivir)
- Lagevrio (molnupiravir)
- bebtelovimab (investigational)
- Veklury (remdesivir)
- Lagevrio (molnupiravir)
- bebtelovimab (investigational)
12
Which of the 3 has the lowest efficacy?
Paxlovid, Veklury, Lagevrio?
Paxlovid, Veklury, Lagevrio?
Lagevrio
13
bebtelovimab should not be used if: (2)
- hospitalized
- requiring oxygen
- requiring oxygen
14
COVID-19
Inpatient Management:
Inpatient Management:
- Supplemental oxygen (if needed)
- Remdesivir (if O2 required)
- Dexamethasone (if O2 required)
- Tocilizumab or Baricitinib (if O2 requirement increases rapidly, must be used with steroids)
- VTE prophylaxis (UFH, or continue home antithrombotic meds, unless CI'd)
- Remdesivir (if O2 required)
- Dexamethasone (if O2 required)
- Tocilizumab or Baricitinib (if O2 requirement increases rapidly, must be used with steroids)
- VTE prophylaxis (UFH, or continue home antithrombotic meds, unless CI'd)
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