Strep Throat

Pharyngitis

Strepococcus pyogenes

Gram-positive cocci (GPC), Numerous virluence factors (including exotoxins, >150 different strains or serotypes/ M-protiens), B-hemolytic, nonmotile, Catalase negative

Human skin and respiratory tract (carriage high as 15-20% in school children)

Mouth and Sinuses

Dircet contact with infected individuals, indirect- inhaled droplets, contaminated food or surfaces

2-5 days

Colonization of tissue aided by virluence factors. Protien F facilitates attachment, the capsule and M protiens inhibit phagocytosis, protien G inhibtis antibody binding, and secreted enzymes damage tissue

Sore/inflamed throat and tonsils red, swollen and sometimes puss; Fever, headache, fatigue- symptoms resolve in 3-7 days; children may experience- nausea, vomiting, abdominal pain

Scarlet fever, cellulitis, tissue damage or abscess, metastatic infection, Streptococcal TSS, post streptococcal glomerulonephritis, Acute Rheumatic fever

most frequent in children 5-15, global incidence .5 mil cases./year; prevelance >15 mil

charecterized by inflammatory lesions involving the heart, joints, subcutanous tissue and central nervous system. Autoimmune etiology

Minor- fever, swollen or painful joints; Major- Carditis, Arthritis, Chorea, Subcutaneous nodules, Erythema marginatum; Untreat symptoms last 3-6 months

Secondary Rheumatic heart disease; permant damage to heart valves, CHF, accounts for 233,000 deaths/year

Avoid crowded areas and infected individuals, practice good hygiene

Penicillian or Amoxicillin; Analgesics for pain