Antimicrobial Drugs Part 2

*interefere with gyrase (topoisomerases, leads to supercoiling)
*inhibit folic acid (vitamin synthesis)
*binds to RNA polymerases to block transcription

*Quinolones
*Sulfonamides
*Metronidazole (flagyl)
*Rifamycin

interfere with bacterial DNA topoisomerases (gyrase) leads to supercoiling (ATTACKS DNA SYNTHESIS)

*binds to rna polymerases and blocks transcription (rifampin) (ATTACKS DNA SYNTHESIS)

*inhibit folic acid (vitamin synthesis)
*broad spectrum
*bacteriostatic
(ATTACK DNA SYNTHESIS)

*only works in reduced form
*damages anaerobic bacteria and protozoans
(ATTACKS DNA SYNTHESIS)

*Aminoglycosides (broad)
*Tetracyclines (broad)
*Chloramphenicol (broad)
*Macrolides (narrow)

*streptomycin
*neomycin
*gentamicin

*erythromycin, blocks binding of rna polymerases, inhibiting transcription

*ergosterol synthesis (messes with membrane)
*cell wall synthesis (inhibits syntehsis of B-glycan)
*nucleic acids (interfers with rna synthesis)
*inhibition of microtubules (messes with mitosis)

*type of antifungal drug
*inhibits ergosterol synthesis (membrane)
*Miconazole and Triazole

*nucleoside and nucleotide analogs

*protease inhibitors (prevents viral proteins from becoming functional by cutting them)
*inhibit attatchment of virus
*inhibit uncoating of virus (can't carry out it's evil plan)