LEC 9 BIOL 431

1. Skin, mucous membrane
2. phagocytic and non phagpocytic cells
3. inflammation
4. anti microbial proteins
5. fever

Skin - Keratin = strong barrier
- acidic skin secretions
Mucouse membrane - acidic GI pH=1 Vagina pH=5
- nasal hairs
- saliva and tears

Phagocytic = microbe adheres and is broken down
non phagocytic (natural killer cells)= kills damaged cells and foreign invaders by punching a whole in membrane w/ perforins

Chemical = Histamines, kinins, prostaglandins, cytokinases
Result = dilation of blood vessels leading to swelling and pain due to pressure on nerve centers

Comoplement and interferons

Group of 20 plasma
Activated by binding of antibody to antigen
Complenments/enhances immune response

Protein secreted by viral infected cells
Stims other cells to produce chemicals to interfere with virus reproduction

Meaning = infection no longer localized (systemic)
Results = production of pyrogen
- increases body temp
- liver spleen withhold iron & zinc to interrupt bacterial growth
- increases metabolism leading to increased repair

Deffinition = Any foreign material that activate the immune system
Types = Complete antigen, Hapten, Self antigen

Contains:
1. Immungenecity = ability to stim specific lymphocyte and antibody prod
2. reactivity = ability to react w/ lymphocytes and antigens

incomplete antigen
does not stim immune until linked with a protein
body wil attacks if linked ( seen as foreign)
Think of a developed allergy over time

MHC proteins found on surface of all cells
Coded by our genes
Think about the complications during blood transfusion

Major Histocompatibility Complex