RBC anisocytosis and anisochromia

Identify the visual display of cell size on the X-axis and cell frequency on the Y-axis.

What are the two parameters specifically calculated from the RBC histogram?

Hematology instruments count cells as RBCs if they have volume sizes between what range?

True or False: Cells counted in the 24 to 36 fL range are included in the final RBC count.

Identify the type of cells that are present in the diluted RBC fluid but are usually statistically insignificant unless their count is significantly elevated.

Fill in the blank: If the RBCs are macrocytic, the RBC histogram curve will shift to the ________.

Fill in the blank: If the RBCs are microcytic, the curve will shift to the ________.

What does it indicate if the RBC histogram curve is bimodal?

Enumeration: List three examples of cases that may cause a bimodal distribution curve.

Identify the term for the average volume of individual RBCs.

What is the formula for calculating MCV?

Identify the MCV classification for values < 80 fL.

Identify the MCV classification for values between 80-100 fL.

Identify the MCV classification for values > 100 fL.

Identify the term for an increased number of red cells with variation in size.

What is the diameter range of normal RBCs (normocytes)?

Identify the term for RBCs larger than 8.0 um, often associated with impaired DNA synthesis.

Identify the term for RBCs smaller than 6.0 um, often associated with defective hemoglobin formation.

Enumeration: List the four ways to detect anisocytosis.

True or False: If the RBC size is equal to the nucleus of a small lymphocyte, there is no anisocytosis.

Fill in the blank: A ________ or ________ curve on a histogram indicates more variation in cell size.

What does a peak near 100 fL with a normal RDW (e.g., 14.1%) represent?

Identify the condition often associated with a microcytic RBC population and a normal RDW (e.g., 13.2%).

In Figure C of the notes, a macrocytic population is shown with an MCV of 119.2 fL and an RDW of ________.

Identify the type of curve shown in Figure D, which has an MCV of 80.2 fL and a markedly high RDW of 37.2%.

What is the reference range for RDW-CV in adults?

True or False: Low RDW values have high clinical significance.

Identify the calculation method for RDW that is dependent on both the width of the distribution curve and the MCV.

Identify the calculation method for RDW where the curve width is measured at 20% above the baseline and is not influenced by MCV.

What is the reference range for RDW-SD?

What is the RDW reference range for newborns?

By what age does a newborn's RDW typically decrease to adult levels?

Identify the condition characterized by a decreased MCV and a normal RDW.

Identify the condition characterized by a normal MCV and an increased RDW.

Identify the condition characterized by an increased MCV and an increased RDW.

Identify the general term for a variation in the normal coloration of RBCs.

Normally, RBCs have a central area of pallor that is approximately ________ the diameter.

Identify the term for red cells with a central pallor greater than 1/3 of the diameter.

In the grading of hypochromia, what grade is assigned when the area of central pallor is 3/4 of the diameter?

What is the specific name for a hypochromic cell that appears as a thin rim of hemoglobin, also known as a ghost cell in urine?

Identify the only disease in which the MCHC is genuinely increased (above 37 g/dL).

Enumeration: What are the three key clinical manifestations of symptomatic Hereditary Spherocytosis (HS)?

True or False: The Direct Antiglobulin Test (DAT) is typically positive in Hereditary Spherocytosis.

Identify the confirmatory test for Hereditary Spherocytosis (HS) using flow cytometry.

Identify the term for larger than normal red cells with a bluish tinge when using Wright's stain.

What causes the bluish tinge in polychromatophilic erythrocytes?

In the grading of polychromasia, what grade is given for a 3% percentage of polychromatophilic RBCs?

Identify the term for an increased number of red cells with variation in shape.

Identify the cell that is almost spherical, lacks central pallor, and is associated with AIHA or burns.

True or False: Spherocytes should be reported if found at the feathered edge of a blood film.

Identify the cell, also known as a "mouth cell," characterized by a slit-like central pallor.

Identify the dehydrated form of a stomatocyte that appears "puddled" at one end.

What is another name for Dehydrated Hereditary Stomatocytosis?