Cell Regulation - Cytotoxic Drugs (generic & brand + Adverse Effects)

- docetaxel (Taxotere) [breast]
- abraxane
- paclitaxel (Taxol/AC-T) [breast]

- cisplatin [leukemia]
- cyclophosphamide [breast]

- methrotrexate [leukemia]
- 5-Fluororacil (5-FU) [breast]

- idarubicin [leukemia]
- daunorubicin [leukemia]
- dactinomycin [leukemia]
- doxorubicin
- (Adriamycin) [breast]

- vincristine (bone marrow sparing, for children) [leukemia]

- skin toxicities
- liver failure
- neuropathies

- cisplatin:
tinnitus, ototoxicity, nephrotoxicity
- cyclophosphamide:
alopecia, hemorrhagic cystitis (bladder inflammation & bleeding)

- hepatotoxicity
- photosensitivity

- cardiac & pulmonary toxicity
- vesicants, can cause severe tissue damage w/ extravagation

- neurotoxicity (numbness, tingling in fingers/toes)
- constipation