12 RhIG

- a pharmaceutical drug that contains anti-D ab
- given to Rh negative mothers who are KNOWN to be negative for allo anti-D AND who have been potentially exposed to Rh+ RBCs (Rh+ baby)

intramuscular injection via a pre-measured syringe (1mL in volume) with attached needle

1. Micro Dose
2. Full Dose

after abortion, miscarriage, or termination of ectopic pregnancy

at 12 weeks gestation (antepartum)

- micro dose = 50 µg of anti-D
- protects against 2.5 mls of Rh+ RBCs or 5 mls of Rh+ WB

after amniocentesis / cordocentesis, abdominal trauma during pregnancy, antepartum, antepartum hemorrhage, or postpartum

- following an abortion or miscarriage after 12 weeks gestation
- ≥ 28 weeks gestation (antepartum)
- Within 72 hours postpartum:
❖ When infant is Rh positive OR the fetus Rh is unknown, e.g., fetal demise / stillborn, miscarriage, etc.
❖ The mother has not developed an allo-anti-D

Full dose = 300 µg of anti-D; protects against 15 ml of Rh+ RBCs or 30 mls of Rh+ WB

Fetal cells vol (from KB Test result) / 30 = # syringes given
❑ When calculating the # of RhIG vials, include 1 decimal place, i.e., X.X
❑ Rounding up or down:
➢ If the decimal number is < 0.5 - round down the calculated value, e.g., 2.2 = 2
➢ If the decimal number is ≥ 0.5 - round up the calculated value, e.g., 2.7 = 3
❑ Because this is a "calculation", it is only an "estimate". Therefore, always add 1 to your calculations to ensure adequate dose, e.g., calculated dose is 2 + 1 = 3; calculated dose is 3 + 1 = 4

1. IV RhIG given when there is accidential transfusion of Rh+ given in large blood volume
2. Treatment of ITP

- when blood volume is larger than 30 mLs
- ex. WinRho - pharmaceutical drug
- BB can calculate amount needed based on quanitity of Rh+ RBCs transfused

- Immune thrombocytopenia purpura (ITP)
- a rare autoimmune disorder that occurs when the body's immune system
destroys platelets, which are blood cells that help blood clot
- results in petechiae