Liver Histopathology

Space between the sinusoid and the hepatocyte

Space of Disse

Fibrous capsule that surround the liver

Macrophage cells that have immune functions; Clear debris, phagocytose foreign pathogens

Modified fibroblasts involved in fibrogenesis; Stores vitamin A; Responsible for fibrosis causes type I collagenn to be deposited instead of type III collagen

Diastase- PAS - stain

In the perisinusoidal space

Each lobule has six acini; Central vein is at its centre and is surround by portal triad

Zone 1 of the liver acinus

Zone three of the liver acinus closest to the central vein

Zone one is oxygen rich; Zone three is oxygen poor

Degeneration and intracellular accumulation; Necrosis and Apoptosis; Inflammation; Regeneration; Fibrosis

Ballooning of the heptocytes due to accumulation of water in them; Causes hepatocytes to have a pale cytoplasm

Biliary deposits which cause a foamy swollen appearance of the hepatocytes

Accumulation of circular fatty droplets within the hepatocytic cytoplasm

Non fatty liver disease; Alcoholic liver disease; Drugs; Viral Hepatitis C

In steatosis clear peripheries are seen but in ballooning peipheries are irregular

Eosinophilic glucbules with a fragmented nucleus which shows a hepatocyte undergoing necrosis

Cell death of individual hepatocytes in a cluster

Severity in acute or active hepatitis

Nuetrophils; Macrophages

Usually via proliferation of hepatocytes and cholangiocytes

Nuclei are darker stained because chromosomes are condensed as cell is in mitosis

Inflammation of the liver

In acute viral hepatits inflammation is scattered throughout the lobule and portal tract - spotty necrosis; In chronic viral hepatitis inflammation is mainly in the portal tracts

Inflammation at the interface between portal tracts and the liver parenchyma, where inflammatory cells extend across the limiting plate and damage periportal hepatocytes

Response to inflammation

Permanent scarring of the liver

Bridging fibrous septa; Parenchymal nodules; Disruption of the liver architecture

Necrosis that spreads from the central vein to the portal tract

Impairment of bile flow in the cannaliculi

Severity of the inflammation of the liver

Severity of the fibrosis of the liver

Malignancy; Gallstones; Primary bilairy cirrhosis

mutation in KRAS gene

Ballooning degeneration

Foamy

Steatosis

Councilman body
Indicates apoptosis

Confluent necrosis

Regenerating hepatocytes
Nucleus stains darkens because under going mitosis

Fibrosis of hepatic tissue

Cholestatic issues - build up bile in the hepayocyte